ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SPG7
Previous Symbol	CMAR
Symbol Alias	CAR, SPG5C
Approved Name	spastic paraplegia 7 (pure and complicated autosomal recessive)
Previous Name	cell matrix adhesion regulator
Name Alias	paraplegin
Location	16q24.3
Position	chr16:89574805-89624174, +
External Links	HGNC: 11237 Entrez Gene: 6687 Ensembl: ENSG00000197912 UCSC: uc002fnj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004222	metalloendopeptidase activity	Molecular Function	IDA[11549317]	33
GO:0005515	protein binding	Molecular Function	IPI[14623864]	910
GO:0008219	cell death	Biological Process		33
GO:0008233	peptidase activity	Molecular Function	TAS[9635427]	15
GO:0007399	nervous system development	Biological Process	TAS[9635427]	54
GO:0008089	anterograde axon cargo transport	Biological Process		2
GO:0006508	proteolysis	Biological Process		102
GO:0007005	mitochondrion organization	Biological Process		5
GO:0005524	ATP binding	Molecular Function		228
GO:0005739	mitochondrion	Cellular Component	TAS[9635427]	183
GO:0051082	unfolded protein binding	Molecular Function	TAS[9635427]	19
GO:0031966	mitochondrial membrane	Cellular Component		12
GO:0030163	protein catabolic process	Biological Process		5
GO:0017111	nucleoside-triphosphatase activity	Molecular Function		5
GO:0016021	integral to membrane	Cellular Component		845
GO:0008270	zinc ion binding	Molecular Function		323

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SPG7 (count: 2)

Gene Symbol	Pathway Count	Pathway List
TPP1	7	protein binding; cell death; peptidase activity; nervous system development; proteolysis; mitochondrion; protein catabolic process;
BCS1L	6	protein binding; mitochondrion organization; ATP binding; mitochondrion; nucleoside-triphosphatase activity; integral to membrane;

Genes shared at least 2 KEGG pathways with SPG7 (count: 0)

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Region: chr16:89574805..89624174 View in gBrowse