ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ALDH1L1
Previous Symbol	FTHFD
Symbol Alias	10-fTHF
Approved Name	aldehyde dehydrogenase 1 family, member L1
Previous Name	formyltetrahydrofolate dehydrogenase
Name Alias	cytosolic 10-formyltetrahydrofolate dehydrogenase
Location	3q21.2
Position	chr3:125822408-125916837, -
External Links	HGNC: 3978 Entrez Gene: 10840 Ensembl: ENSG00000144908 UCSC: uc003eim.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs4374483	Chr3:125920064(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs12695477	Chr3:125913874(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6782537	Chr3:125888991(Fwd)	NMD_transcript_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003824	catalytic activity	Molecular Function	TAS[10204077]	15
GO:0005739	mitochondrion	Cellular Component		183
GO:0006730	one-carbon metabolic process	Biological Process		9
GO:0008168	methyltransferase activity	Molecular Function		8
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	Molecular Function		1
GO:0009058	biosynthetic process	Biological Process		2
GO:0009258	10-formyltetrahydrofolate catabolic process	Biological Process		1
GO:0016155	formyltetrahydrofolate dehydrogenase activity	Molecular Function		1
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Molecular Function		1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00670	One carbon pool by folate	6

Genes shared at least 5 GO terms with ALDH1L1 (count: 0)

Genes shared at least 2 KEGG pathways with ALDH1L1 (count: 0)

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Region: chr3:125822408..125916837 View in gBrowse