ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ATP8B1
Previous Symbol	FIC1, BRIC, PFIC1
Symbol Alias	ATPIC, PFIC
Approved Name	ATPase, aminophospholipid transporter, class I, type 8B, member 1
Previous Name	ATPase, Class I, type 8B, member 1, "ATPase, class I, type 8B, member 1"
Location	18q21
Position	chr18:55313658-55470327, -
External Links	HGNC: 3706 Entrez Gene: 5205 Ensembl: ENSG00000081923 UCSC: uc002lgw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IMP[16628629]	64
GO:0055085	transmembrane transport	Biological Process		82
GO:0000287	magnesium ion binding	Molecular Function		28
GO:0005783	endoplasmic reticulum	Cellular Component		100
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function		910
GO:0004012	phospholipid-translocating ATPase activity	Molecular Function	TAS[12880872]	3
GO:0006812	cation transport	Biological Process		8
GO:0006200	ATP catabolic process	Biological Process	RCA[9500542]	6
GO:0005887	integral to plasma membrane	Cellular Component	NAS[12880872]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0016324	apical plasma membrane	Cellular Component	IDA[11682026]	51
GO:0015721	bile acid and bile salt transport	Biological Process	NAS[12880872]	4
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	Molecular Function		4
GO:0008206	bile acid metabolic process	Biological Process		8
GO:0045332	phospholipid translocation	Biological Process		4
GO:0034220	ion transmembrane transport	Biological Process		11
GO:0031526	brush border membrane	Cellular Component		6
GO:0016887	ATPase activity	Molecular Function	RCA[12880872]	14

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ATP8B1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ATP10A	11	transmembrane transport; magnesium ion binding; endoplasmic reticulum; ATP binding; protein binding; phospholipid-translocating ATPase activity; cation transport; plasma membrane; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; phospholipid translocation; ion transmembrane transport;
ATP11A	9	magnesium ion binding; endoplasmic reticulum; ATP binding; protein binding; phospholipid-translocating ATPase activity; cation transport; plasma membrane; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; phospholipid translocation;
ABCC1	6	transmembrane transport; ATP binding; ATP catabolic process; integral to plasma membrane; plasma membrane; ATPase activity;
ABCA1	6	ATP binding; protein binding; integral to plasma membrane; plasma membrane; phospholipid translocation; ATPase activity;
SLC22A11	5	transmembrane transport; protein binding; integral to plasma membrane; plasma membrane; apical plasma membrane;
SLC34A2	5	transmembrane transport; integral to plasma membrane; plasma membrane; apical plasma membrane; brush border membrane;
SLCO1B3	5	transmembrane transport; integral to plasma membrane; plasma membrane; bile acid and bile salt transport; bile acid metabolic process;
HSPA5	5	endoplasmic reticulum; ATP binding; protein binding; ATP catabolic process; ATPase activity;
THY1	5	endoplasmic reticulum; protein binding; integral to plasma membrane; plasma membrane; apical plasma membrane;
CHD1L	5	ATP binding; protein binding; ATP catabolic process; plasma membrane; ATPase activity;

Genes shared at least 2 KEGG pathways with ATP8B1 (count: 0)

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Region: chr18:55313658..55470327 View in gBrowse