ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SLCO1B3
Previous Symbol	SLC21A8
Symbol Alias	OATP8, OATP1B3
Approved Name	solute carrier organic anion transporter family, member 1B3
Previous Name	solute carrier family 21 (organic anion transporter), member 8
Location	12p12
Position	chr12:20963638-21069658, +
External Links	HGNC: 10961 Entrez Gene: 28234 Ensembl: ENSG00000111700 UCSC: uc001rek.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation
rs10277729	Chr12:21106269(Fwd); Chr2:199551733(Fwd); Chr3:105869587(Rev); Chr3:137375274(Fwd); Chr5:180318930(Fwd); Chr9:16225553(Fwd); ChrX:8743218(Fwd)	feature_elongation; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0055085	transmembrane transport	Biological Process		82
GO:0015721	bile acid and bile salt transport	Biological Process		4
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0015711	organic anion transport	Biological Process	TAS[10779507]	3
GO:0043252	sodium-independent organic anion transport	Biological Process		4
GO:0016323	basolateral plasma membrane	Cellular Component		29
GO:0005887	integral to plasma membrane	Cellular Component	TAS[10779507]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0008514	organic anion transmembrane transporter activity	Molecular Function	TAS[10779507]	5
GO:0008206	bile acid metabolic process	Biological Process		8
GO:0005737	cytoplasm	Cellular Component		690

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04976	Bile secretion	13	Bile is a vital secretion, essential for digestion and absor...... Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. More...

Genes shared at least 5 GO terms with SLCO1B3 (count: 5)

Gene Symbol	Pathway Count	Pathway List
SLC22A6	7	transmembrane transport; organic anion transport; sodium-independent organic anion transport; basolateral plasma membrane; integral to plasma membrane; plasma membrane; organic anion transmembrane transporter activity;
AQP4	5	transmembrane transport; basolateral plasma membrane; integral to plasma membrane; plasma membrane; cytoplasm;
ATP8B1	5	transmembrane transport; bile acid and bile salt transport; integral to plasma membrane; plasma membrane; bile acid metabolic process;
SLC22A11	5	transmembrane transport; organic anion transport; integral to plasma membrane; plasma membrane; organic anion transmembrane transporter activity;
ADRA2A	5	small molecule metabolic process; basolateral plasma membrane; integral to plasma membrane; plasma membrane; cytoplasm;

Genes shared at least 2 KEGG pathways with SLCO1B3 (count: 0)

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Region: chr12:20963638..21069658 View in gBrowse