ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs2242447 dbSNP Ensembl
Location chr16:55735912(Fwd)
Variant Alleles C/T
Ancestral Allele C
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000219833; ENST00000379906; ENST00000414754; ENST00000561820; ENST00000566163; ENST00000567238; ENST00000568943; ENST00000574918)
No. of Studies 7 (significant: 2; non-significant: 5; trend: 0)
Source Literature-origin

SNP related studies (count: 7)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Gizer IR, 2009 Meta-analysis model: Random: OR=1.04, 95% CI=0.91-1.19, two-...... Meta-analysis model: Random: OR=1.04, 95% CI=0.91-1.19, two-tailed P-value=0.589; Q-statistic: P-value=0.319, I2=14 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Brookes K, 2006 A/G UNPHASED TDT P-value=0.703; WHAP TDT P-value=0.912 UNPHASED TDT P-value=0.703; WHAP TDT P-value=0.912 no significant association was observed no significant association was observed Non-significant
Pazvantoglu, O.,2013 C/T genotype: (CC vs CT vs TT), chi-square tests, P-value=0.008,...... genotype: (CC vs CT vs TT), chi-square tests, P-value=0.008, X2=13.888; allele: chi-square tests, P-value=0.013, X2=8.700 among groups; genotypic P-value=0.019, allelic P-value = 0.003, X2=8.694, df=1 between the ADHD and the Non-ADHD groups; Presence of the C allele (CC + CT): P-value=0.014, X2=8.581, df=2, among the groups; X2= 7.125, df = 1, P-value = 0.008 between the ADHD and the Non-ADHD groups; Presence of the T allele (TT + CT): X2=6.229, df=2, P-value = 0.044, correction P-value>0.017 among the groups More... A significant difference was determined between the groups f...... A significant difference was determined between the groups for NET1 (rs2242447). The significant difference for NET1 (rs2242447) was between the ADHD and Non-ADHD groups. The C allele had a higher frequency in the ADHD group, and the T allele in the Non-ADHD group. There were no differences in allele frequencies for NET1 (rs2242447) between the Non-ADHD and HC groups, or the ADHD and HC groups, after the Bonferroni correction. The NET1 (rs2242447) C allele presence was significantly lower in the Non-ADHD group compared to both the ADHD and HC groups. There was no significant difference in terms of allele presence between the ADHD and HC groups after the Bonferroni correction. Nevertheless, while there was a statistically significant difference in the rates of allele presence of the NET1 (rs2242447) T allele in three-group comparison, there was no significant difference in two-group comparisons after the Bonferroni correction. More... Significant
Hawi, Z., 2012 T:C T P-value=0.0065*, X2=7.42, OR=1.47, 95% CI=1.11-1....... P-value=0.0065*, X2=7.42, OR=1.47, 95% CI=1.11-1.94 More... Nominal associations between ADHD and the marker was observe...... Nominal associations between ADHD and the marker was observed. However, the association did not remain significant after adjusting the p values using 10,000 permutations. More... Significant
Xu X, 2005(a) TDT P-value=0.07, OR=1.17 TDT P-value=0.07, OR=1.17 no evidence for association no evidence for association Non-significant
Sengupta, S. M., 2012 T/C P-value=0.25, Z statistic (allele 1)=1.15 P-value=0.25, Z statistic (allele 1)=1.15 No significant association was found in this study. No significant association was found in this study. Non-significant
Ilott NE, 2010 QTDT AT P-value=0.27, X2=1.23, df=1, QTDT AW P-va...... QTDT AT P-value=0.27, X2=1.23, df=1, QTDT AW P-value=0.31, X2=1.03, df=1 at age 2; QTDT AT P-value=0.18, X2=3.56, df=1, QTDT AW P-value=0.16, X2=2.01, df=1 at age 3 More... no significant association no significant association Non-significant

SNP related genes (count: 2)

Literature-origin genes (count: 2)

Genes from other sources Help (count: 0)


SNPs in LD with rs2242447 (count: 4) View in gBrowse (chr16:55735912..55782924 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)