ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Joung Y, 201019685476
Citation	Joung Y., Kim C. H., Moon J., Jang W. S., Yang J., Shin D., Lee S. and Kim K. S. (2010) "Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population." Am J Med Genet B Neuropsychiatr Genet, 153B(2): 691-4.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	103 unrelated males with ADHD and 103 normal male controls
Predominant Ethnicity	Mongoloid
Population	Korea
Gender	all are males
Age Group	Children/Adolescents : 6-14 years

Detail Info

Summary	To determine possible roles of the SLC6A2 as a susceptibility gene for ADHD, they performed the genetic association study for a functional -3081(A/T) polymorphism, located in the promoter region of SLC6A2. For the present study of association between ADHD and the SLC6A2, 103 male patients with ADHD and 103 normal male controls were randomly gathered. Significant differences were found in the allele frequencies (X² =5.60, P-value=0.02) and the odds ratio for the allele T between the ADHD and normal subjects was 1.59 (95% CI: 1.08-2.34) suggesting that T allele is critical to make the group difference. Significant group difference was also found in AA, AT, TT genotypes (X²=7.1, P-value=0.02). The odds ratio for TT and AT genotypes was 4.57 (95% CI: 2.56-8.15) and 1.96 (95% CI: 0.96-3.78), respectively. Findings in the present study provided further evidence of association between ADHD and -3081(A/T) polymorphism of SLC6A2.
Total Sample	A total of 103 unrelated males with ADHD and 103 normal male controls were included in this study, all of whom were Korean. The cases were selected from among the patients treated at the Samsung Medical Center ADHD Clinic between March 2004 and February 2007. The normal controls were volunteers randomly recruited from a middle school in Seoul.
Sample Collection	Asian_Korean
Diagnosis Description	A total of 103 unrelated males with ADHD and 103 normal male controls were included in this study, all of whom were Korean. The patients were children and adolescents, with range from 6 to 14 years, who met the DSM-IV-TR criteria for ADHD, were determined by clinical assessment and semi-structured interview of Korean version of K-SADS-PL. The exclusion criteria included any serious medical illnesses, psychosis, bipolar disorder, a history of a seizure disorder, learning disorder, and autism spectrum disorder including Asperger's disorder. All of the control subjects were screened for apparent medical illness, ADHD, learning disorder, or mental retardation by means of a teacher's and parent's informal report, the ADHD RSIV- teacher scale (teacher's rating score <18), and a school record. None of the control had any history of medical or psychiatric illness.
Technique	The analysis of genomic DNA samples was carried out under the conditions used in our previous study [Kim et al., 2006]. Please refer to the original article for details.
Analysis Method	Chi-square analysis with a two-tailed p-value was used to compare the allele and genotype frequencies between the patients and controls. Fisher's exact test with the permutation method was used for multiple testings to compare the frequencies of the three types of genotypes. Allele frequencies were calculated and analyzed using the SPSS statistical package version 17.0. The genotype and allele odds ratios were estimated by logistic regression using additive model. The genotype distribution and allele frequencies in the three subgroups of ADHD were analyzed by using chi-square test. The ANOVA was used to compare the symptom severity among the subjects with three genotypes.
Result Description	Significant differences were found in the allele frequencies (X²=5.60, P-value=0.02) and the odds ratio for the allele T between the ADHD and normal subjects was 1.59 (95% CI: 1.08-2.34) suggesting that T allele is critical to make the group difference. Significant group difference was also found in AA, AT, TT genotypes (X²=7.1, P-value=0.02). The odds ratio for TT and AT genotypes was 4.57 (95% CI: 2.56-8.15) and 1.96 (95% CI: 0.96-3.78), respectively. Findings in the present study provided further evidence of association between ADHD and -3081(A/T) polymorphism of SLC6A2.

Other variant reported by this study (count: 1)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
SLC6A2 promoter -3081A/T	A/T		logistic regression P-value=0.02, X²=5.60 in the ...... logistic regression P-value=0.02, X²=5.60 in the allele frequencies, OR=1.59 for T allele; logistic regression P-value=0.02, X²=7.1 in the genotype frequencies, OR=4.57 for TT and OR=1.96 for AT More...	provided further evidence of association	Significant

Genes reported by this study (count: 1)