Study Report

Basic Info
Reference |
Joung Y, 201019685476
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Citation |
Joung Y., Kim C. H., Moon J., Jang W. S., Yang J., Shin D., Lee S. and Kim K. S. (2010) "Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population." Am J Med Genet B Neuropsychiatr Genet, 153B(2): 691-4.
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Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
103 unrelated males with ADHD and 103 normal male controls |
Predominant Ethnicity |
Mongoloid |
Population |
Korea |
Gender |
all are males |
Age Group |
Children/Adolescents
:
6-14 years
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Detail Info
Summary |
To determine possible roles of the SLC6A2 as a susceptibility gene for ADHD, they performed the genetic association study for a functional -3081(A/T) polymorphism, located in the promoter region of SLC6A2. For the present study of association between ADHD and the SLC6A2, 103 male patients with ADHD and 103 normal male controls were randomly gathered. Significant differences were found in the allele frequencies (X2 =5.60, P-value=0.02) and the odds ratio for the allele T between the ADHD and normal subjects was 1.59 (95% CI: 1.08-2.34) suggesting that T allele is critical to make the group difference. Significant group difference was also found in AA, AT, TT genotypes (X2=7.1, P-value=0.02). The odds ratio for TT and AT genotypes was 4.57 (95% CI: 2.56-8.15) and 1.96 (95% CI: 0.96-3.78), respectively. Findings in the present study provided further evidence of association between ADHD and -3081(A/T) polymorphism of SLC6A2. |
Total Sample |
A total of 103 unrelated males with ADHD and 103 normal male controls were included in this study, all of whom were Korean. The cases were selected from among the patients treated at the Samsung Medical Center ADHD Clinic between March 2004 and February 2007. The normal controls were volunteers randomly recruited from a middle school in Seoul. |
Sample Collection |
Asian_Korean |
Diagnosis Description |
A total of 103 unrelated males with ADHD and 103 normal male controls were included in this study, all of whom were Korean. The patients were children and adolescents, with range from 6 to 14 years, who met the DSM-IV-TR criteria for ADHD, were determined by clinical assessment and semi-structured interview of Korean version of K-SADS-PL. The exclusion criteria included any serious medical illnesses, psychosis, bipolar disorder, a history of a seizure disorder, learning disorder, and autism spectrum disorder including Asperger's disorder. All of the control subjects were screened for apparent medical illness, ADHD, learning disorder, or mental retardation by means of a teacher's and parent's informal report, the ADHD RSIV- teacher scale (teacher's rating score <18), and a school record. None of the control had any history of medical or psychiatric illness. |
Technique |
The analysis of genomic DNA samples was carried out under the conditions used in our previous study [Kim et al., 2006]. Please refer to the original article for details. |
Analysis Method |
Chi-square analysis with a two-tailed p-value was used to compare the allele and genotype frequencies between the patients and controls. Fisher's exact test with the permutation method was used for multiple testings to compare the frequencies of the three types of genotypes. Allele frequencies were calculated and analyzed using the SPSS statistical package version 17.0. The genotype and allele odds ratios were estimated by logistic regression using additive model. The genotype distribution and allele frequencies in the three subgroups of ADHD were analyzed by using chi-square test. The ANOVA was used to compare the symptom severity among the subjects with three genotypes. |
Result Description |
Significant differences were found in the allele frequencies (X2=5.60, P-value=0.02) and the odds ratio for the allele T between the ADHD and normal subjects was 1.59 (95% CI: 1.08-2.34) suggesting that T allele is critical to make the group difference. Significant group difference was also found in AA, AT, TT genotypes (X2=7.1, P-value=0.02). The odds ratio for TT and AT genotypes was 4.57 (95% CI: 2.56-8.15) and 1.96 (95% CI: 0.96-3.78), respectively. Findings in the present study provided further evidence of association between ADHD and -3081(A/T) polymorphism of SLC6A2. |

Other variant reported by this study (count: 1)
Variant Name |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
SLC6A2 promoter -3081A/T |
A/T |
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logistic regression P-value=0.02, X2=5.60 in the ......
logistic regression P-value=0.02, X2=5.60 in the allele frequencies, OR=1.59 for T allele; logistic regression P-value=0.02, X2=7.1 in the genotype frequencies, OR=4.57 for TT and OR=1.96 for AT
More...
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provided further evidence of association |
Significant
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Genes reported by this study (count: 1)
Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
SLC6A2 |
significant differences in the allele and genotypes frequenc......
significant differences in the allele and genotypes frequencies of SLC6A2 -3081(A/T) polymorphism between cases and controls
More...
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Significant
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