ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04540
Name Gap junction
No. of Genes in ADHDgene  30
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 30)

Literature-origin genes (count: 9)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 13(7/6/0)
PRKG1 protein kinase, cGMP-dependent, type I 10q11.2 2(0/1/1)
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0)
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0)
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 5(2/3/0)
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0)
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1)
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0)

Genes from other sources Help(count: 21)

Approved Symbol Approved Name Location Source
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
TUBA4A tubulin, alpha 4a 2q36.1 Mapped by significant region
TUBA3E tubulin, alpha 3e 2q21.1 Mapped by significant region
LPAR1 lysophosphatidic acid receptor 1 9q Mapped by significant region
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 3p26.1 Mapped by CNV
GJA1 gap junction protein, alpha 1, 43kDa 6q22.31 Mapped by Literature SNP; Mapped by significant region
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 11q21-q22 Mapped by significant region
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
TUBA3C tubulin, alpha 3c 13q12.11 Mapped by significant region
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 12p11.23 Mapped by Literature SNP
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region
MAPK7 mitogen-activated protein kinase 7 17p11.2 Mapped by significant region
TUBB3 tubulin, beta 3 class III 16q24.3 Mapped by significant region
ADCY2 adenylate cyclase 2 (brain) 5p15.3 Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
ADCY3 adenylate cyclase 3 2p23.3 Mapped by LD-proxy
PLCB2 phospholipase C, beta 2 15q15.1 Mapped by PBA pathway
TJP1 tight junction protein 1 15q13 Mapped by CNV; Mapped by significant region
PDGFD platelet derived growth factor D 11q22.3 Mapped by significant region
TUBA3D tubulin, alpha 3d 2q21.1 Mapped by CNV; Mapped by significant region
ADCY9 adenylate cyclase 9 16p13.3 Mapped by significant region