ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs1051312 dbSNP Ensembl
Location	chr20:10287088(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000254976; ENST00000304886) intron_variant(ENST00000421143; ENST00000453544) nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883) non_coding_exon_variant(ENST00000495883)
No. of Studies	12 (significant: 2; non-significant: 10; trend: 0)
Source	Literature-origin

SNP related studies (count: 12)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Mill J, 2004 (b)	T/C		allelic TDT P-value=0.16, X²=1.95; HHRR P-value=0...... allelic TDT P-value=0.16, X²=1.95; HHRR P-value=0.21, X²=1.56; PDT P-value=0.17, X²=1.90, TRANSMIT P-value=0.25, X²=1.33 in parental samples. More...	the marker was not individually associated with ADHD in this...... the marker was not individually associated with ADHD in this sample More...	Non-significant
Kustanovich V, 2003	T/C		allelic TDT P-value=0.420, allelic TDT P-value=0.131 for pat...... allelic TDT P-value=0.420, allelic TDT P-value=0.131 for paternal transmission More...	TDT of individual alleles did not reach statistical signific...... TDT of individual alleles did not reach statistical significance More...	Non-significant
Ilott NE, 2010			QTDT AT P-value=0.43, X²=0.63, df=1, QTDT AW P-va...... QTDT AT P-value=0.43, X²=0.63, df=1, QTDT AW P-value=0.85, X²=0.04, df=1 at age 2; QTDT AT P-value=0.58, X²=0, df=1, QTDT AW P-value=0.42, X²=0.65, df=1 at age 3 More...	no significant association no significant association	Non-significant
Pazvantoglu, O.,2013	C/T		genotype: (CC vs CT vs TT), chi-square tests, P-value=0.279,...... genotype: (CC vs CT vs TT), chi-square tests, P-value=0.279, X²=5.084; allele: chi-square tests, P-value=0.692, X²=0.736 among the groups More...	No significant difference was observed between the groups in...... No significant difference was observed between the groups in terms of allele frequencies for SNAP-25 (rs1051312). More...	Non-significant
Feng Y, 2005(b)	T/C		allelic TDT P-value=0.286, X²=1.14 in Irvine samp...... allelic TDT P-value=0.286, X²=1.14 in Irvine sample; allelic TDT P-value=0.933, X²=0.007 in Toronto sample More...	there was no significant result both in the Toronto sample a...... there was no significant result both in the Toronto sample and the Irvine sample More...	Non-significant
Sarkar, K., 2012	T/C		allelic P-value=1, X²=0.0 for case-control, P-va...... allelic P-value=1, X²=0.0 for case-control, P-value=1, X²=0.0 for family-based; genotypic P-value=0.09, X²=4.78 for case-control, P-value=0.32, X²=2.28 for family-based; X²=1.8, TDT P-value=0.18, Relative risk (95% CI)=2.25 (1.0¨C5.22) More...	Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. rs362569 and rs1051312 failed to reveal any preferential transmission. More...	Non-significant
Kim JW, 2007	T/C	C	Combined TDT P-value=0.69 (OR=1.03); Single marker analysis ...... Combined TDT P-value=0.69 (OR=1.03); Single marker analysis FBAT P-value=0.894; Exploratory analyses FBAT P-value=0.475 for co-morbid CD, P-value=0.211 for co-morbid MDD, P-value=0.219 for co-morbid BD More...	No association was found between ADHD or co-morbidities of A...... No association was found between ADHD or co-morbidities of ADHD and this SNP More...	Non-significant
Gizer IR, 2009			Meta-analysis model: Random: OR=1.06, 95% CI=0.86-1.31, P-va...... Meta-analysis model: Random: OR=1.06, 95% CI=0.86-1.31, P-value=0.298; Q-statistic: P-value=0.084, I²=48 More...	no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More...	Non-significant
Forero DA, 2009	C/T			Not significant for the total samples. Not significant for the total samples.	Non-significant
Barr CL, 2000 (a)	T/C		TDT P-value=0.074 TDT P-value=0.074	no significant evidence for biased transmission no significant evidence for biased transmission	Non-significant
Galvez, J. M.,2013	C/T		Allele P-value = 0.05 after Bonferroni correction; genotype ...... Allele P-value = 0.05 after Bonferroni correction; genotype P-value = 0.009 after Bonferroni correction. More...	Significant association was observed Significant association was observed	Significant
Brophy K, 2002	T/C	DdeI	HHRR analysis: overall P-value=0.01, RR=1.51; paternal trans...... HHRR analysis: overall P-value=0.01, RR=1.51; paternal transmission P-value=0.019, RR=2.0; maternal transmission P-value=0.10, RR=1.45; TDT analysis: overall P-value=0.015, RR=2.13; paternal transmission P-value=0.013, RR=6.0; maternal transmission P-value=0.17, RR=1.9 More...	increased preferential transmission was found increased preferential transmission was found	Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Genes from other sources (count: 1)

SNPs in LD with rs1051312 (count: 0) View in gBrowse (chr20:10287088..10287088 )