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Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
Data Summary
SNP Report
Name | rs1051312 dbSNP Ensembl | ||
---|---|---|---|
Location | chr20:10287088(Fwd) | ||
Variant Alleles | T/C | ||
Ancestral Allele | T | ||
Functional Annotation | 3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant. | ||
Consequence to Transcript | 3_prime_UTR_variant(ENST00000254976; ENST00000304886) intron_variant(ENST00000421143; ENST00000453544) nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883) non_coding_exon_variant(ENST00000495883) |
||
No. of Studies | 12 (significant: 2; non-significant: 10; trend: 0) | ||
Source | Literature-origin |
Reference | Allele Change | Risk Allele | Statistical Values | Author Comments | Result of Statistical Analysis |
---|---|---|---|---|---|
Mill J, 2004 (b) | T/C | allelic TDT P-value=0.16, X2=1.95; HHRR P-value=0...... allelic TDT P-value=0.16, X2=1.95; HHRR P-value=0.21, X2=1.56; PDT P-value=0.17, X2=1.90, TRANSMIT P-value=0.25, X2=1.33 in parental samples. More... | the marker was not individually associated with ADHD in this...... the marker was not individually associated with ADHD in this sample More... | Non-significant | |
Kustanovich V, 2003 | T/C | allelic TDT P-value=0.420, allelic TDT P-value=0.131 for pat...... allelic TDT P-value=0.420, allelic TDT P-value=0.131 for paternal transmission More... | TDT of individual alleles did not reach statistical signific...... TDT of individual alleles did not reach statistical significance More... | Non-significant | |
Ilott NE, 2010 | QTDT AT P-value=0.43, X2=0.63, df=1, QTDT AW P-va...... QTDT AT P-value=0.43, X2=0.63, df=1, QTDT AW P-value=0.85, X2=0.04, df=1 at age 2; QTDT AT P-value=0.58, X2=0, df=1, QTDT AW P-value=0.42, X2=0.65, df=1 at age 3 More... | no significant association no significant association | Non-significant | ||
Pazvantoglu, O.,2013 | C/T | genotype: (CC vs CT vs TT), chi-square tests, P-value=0.279,...... genotype: (CC vs CT vs TT), chi-square tests, P-value=0.279, X2=5.084; allele: chi-square tests, P-value=0.692, X2=0.736 among the groups More... | No significant difference was observed between the groups in...... No significant difference was observed between the groups in terms of allele frequencies for SNAP-25 (rs1051312). More... | Non-significant | |
Feng Y, 2005(b) | T/C | allelic TDT P-value=0.286, X2=1.14 in Irvine samp...... allelic TDT P-value=0.286, X2=1.14 in Irvine sample; allelic TDT P-value=0.933, X2=0.007 in Toronto sample More... | there was no significant result both in the Toronto sample a...... there was no significant result both in the Toronto sample and the Irvine sample More... | Non-significant | |
Sarkar, K., 2012 | T/C | allelic P-value=1, X2=0.0 for case-control, P-va...... allelic P-value=1, X2=0.0 for case-control, P-value=1, X2=0.0 for family-based; genotypic P-value=0.09, X2=4.78 for case-control, P-value=0.32, X2=2.28 for family-based; X2=1.8, TDT P-value=0.18, Relative risk (95% CI)=2.25 (1.0¨C5.22) More... | Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. rs362569 and rs1051312 failed to reveal any preferential transmission. More... | Non-significant | |
Kim JW, 2007 | T/C | C | Combined TDT P-value=0.69 (OR=1.03); Single marker analysis ...... Combined TDT P-value=0.69 (OR=1.03); Single marker analysis FBAT P-value=0.894; Exploratory analyses FBAT P-value=0.475 for co-morbid CD, P-value=0.211 for co-morbid MDD, P-value=0.219 for co-morbid BD More... | No association was found between ADHD or co-morbidities of A...... No association was found between ADHD or co-morbidities of ADHD and this SNP More... | Non-significant |
Gizer IR, 2009 | Meta-analysis model: Random: OR=1.06, 95% CI=0.86-1.31, P-va...... Meta-analysis model: Random: OR=1.06, 95% CI=0.86-1.31, P-value=0.298; Q-statistic: P-value=0.084, I2=48 More... | no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... | Non-significant | ||
Forero DA, 2009 | C/T | Not significant for the total samples. Not significant for the total samples. | Non-significant | ||
Barr CL, 2000 (a) | T/C | TDT P-value=0.074 TDT P-value=0.074 | no significant evidence for biased transmission no significant evidence for biased transmission | Non-significant | |
Galvez, J. M.,2013 | C/T | Allele P-value = 0.05 after Bonferroni correction; genotype ...... Allele P-value = 0.05 after Bonferroni correction; genotype P-value = 0.009 after Bonferroni correction. More... | Significant association was observed Significant association was observed | Significant | |
Brophy K, 2002 | T/C | DdeI | HHRR analysis: overall P-value=0.01, RR=1.51; paternal trans...... HHRR analysis: overall P-value=0.01, RR=1.51; paternal transmission P-value=0.019, RR=2.0; maternal transmission P-value=0.10, RR=1.45; TDT analysis: overall P-value=0.015, RR=2.13; paternal transmission P-value=0.013, RR=6.0; maternal transmission P-value=0.17, RR=1.9 More... | increased preferential transmission was found increased preferential transmission was found | Significant |
Literature-origin genes (count: 1)

Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend) ![]() |
---|---|---|---|
SNAP25 | synaptosomal-associated protein, 25kDa | 20p12-p11.2 | 21(16/5/0) |
Genes from other sources
(count: 1)

Approved Symbol | Approved Name | Location |
---|---|---|
SNAP25-AS1 | SNAP25 antisense RNA 1 | 20p12.2 |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014