ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1843809 dbSNP Ensembl
Location	Chr12:72348698(Fwd)
Variant Alleles	G/T
Ancestral Allele	G
Functional Annotation	NMD_transcript_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000546576) intron_variant(ENST00000546576; ENST00000333850)
No. of Studies	5 (significant: 3; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/C		UNPHASED TDT P-value=0.00482; WHAP TDT P-value=0.012 UNPHASED TDT P-value=0.00482; WHAP TDT P-value=0.012	positive but with opposite allele, significant association w...... positive but with opposite allele, significant association was observed in both UNPHASED and WHAP analyses More...	Significant
Sheehan K, 2007		T	TDT test: P-value=1, OR=1.05 for full trios; P-value=0.302, ...... TDT test: P-value=1, OR=1.05 for full trios; P-value=0.302, OR=0.5 for paternal transmission; P-value=0.327, OR=1.6 for maternal transmission. More...	There is no significant difference in the transmission of al...... There is no significant difference in the transmission of alleles to ADHD cases. More...	Non-significant
Hawi Z, 2005			TDT P-value=0.001, X²=10.9, OR=3.7 for paternel t...... TDT P-value=0.001, X²=10.9, OR=3.7 for paternel transmission; TDT P-value=0.09, X²=3.5, OR=1.9 for maternal transmission More...	nominal significant overtransmission of paternal alleles was...... nominal significant overtransmission of paternal alleles was seen, no significant association was observed for maternal transmission More...	Significant
Gizer IR, 2009			Meta-analysis model: Random: OR=1.15, 95% CI=0.73-1.82, P-va...... Meta-analysis model: Random: OR=1.15, 95% CI=0.73-1.82, P-value=0.276; Q-statistic: P-value=0.0002, I²=84 More...	no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More...	Non-significant
Sheehan K, 2005	T/G		allelic TDT P-value=0.0006, X²=12.2, OR=2.36; TDT...... allelic TDT P-value=0.0006, X²=12.2, OR=2.36; TDT P-value=0.001, X²=10.9, OR=3.7 of paternal origin; TDT P-value=0.09, X²=3.5, OR=1.9 of maternal origin More...	a highly significant association between the T allele and AD...... a highly significant association between the T allele and ADHD was observed; association is enhanced when paternal transmission alone is considered More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

Genes from other sources (count: 0)

SNPs in LD with rs1843809 (count: 29) View in gBrowse (chr12:72344618..72398117 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 13)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6582081	intron_variant	1(1/0/0)	0.831[CEU]; 0.846[CHB]; 0.846[CHD]; 0.883[GIH]; 1.0[TSI]
rs4760818	intron_variant	2(1/1/0)	0.913[CEU]; 0.823[CHB]; 0.826[GIH]; 0.865[MEX]
rs1386496	NMD_transcript_variant; intron_variant	2(0/2/0)	1.0[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 0.865[MEX]; 1.0[TSI]
rs1386493	NMD_transcript_variant; intron_variant	4(2/2/0)	0.847[CEU]
rs7955501	NMD_transcript_variant; intron_variant	1(0/1/0)	0.896[YRI]
rs1386494	NMD_transcript_variant; intron_variant	1(0/1/0)	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs1386488	NMD_transcript_variant; intron_variant	2(0/2/0)	0.847[CEU]
rs1007023	intron_variant	1(1/0/0)	0.913[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 0.859[MEX]; 0.96[TSI]
rs4760814	intron_variant	1(0/1/0)	0.913[CEU]; 1.0[CHB]
rs7963226	intron_variant	1(1/0/0)	0.913[CEU]; 0.846[CHB]; 0.846[CHD]; 0.883[GIH]; 1.0[TSI]
rs1386497	intron_variant	2(1/1/0)	0.913[CEU]; 0.846[CHB]; 0.8[MEX]; 0.893[TSI]
rs7954568	intron_variant	1(1/0/0)	0.906[CEU]; 1.0[CHB]
rs6582072	NMD_transcript_variant; intron_variant	1(0/1/0)	0.847[CEU]

LD-proxies (count: 16)

rs_ID	Functional Annotation	r²[population]
rs990234	intron_variant	0.831[CEU]
rs1487281	intron_variant	0.913[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 1.0[TSI]
rs2046582	intron_variant	0.912[CEU]; 1.0[CHB]; 1.0[JPT]
rs2367899	intron_variant	0.913[CEU]; 1.0[CHB]
rs7968346	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs7300490	intron_variant	0.913[CEU]
rs4760751	intron_variant	0.913[CEU]; 1.0[CHB]; 0.846[CHD]; 0.877[GIH]; 0.865[MEX]; 1.0[TSI]
rs1386490	NMD_transcript_variant; intron_variant	0.912[CEU]; 1.0[CHB]; 1.0[JPT]
rs11830353	NMD_transcript_variant; intron_variant	1.0[JPT]
rs10748189	intron_variant	0.831[CEU]; 1.0[CHB]
rs10784944	downstream_gene_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.859[MEX]; 1.0[TSI]
rs4760749	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]
rs7299582	3_prime_UTR_variant; NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.859[MEX]; 1.0[TSI]
rs1843812	intron_variant	0.913[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 0.865[MEX]; 0.96[TSI]
rs1386489	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.865[MEX]; 1.0[TSI]
rs10784942	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]