ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs1386493 dbSNP Ensembl
Location chr12:72355179(Fwd)
Variant Alleles A/G
Ancestral Allele G
Functional Annotation intron_variant; nc_transcript_variant.
Consequence to Transcript intron_variant(ENST00000333850; ENST00000546576)
nc_transcript_variant(ENST00000546576)
No. of Studies 5 (significant: 2; non-significant: 3; trend: 0)
Source Literature-origin

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Sheehan K, 2007 C TDT test: P-value=0.775, OR=0.89 for full trios; P-value=0.8...... TDT test: P-value=0.775, OR=0.89 for full trios; P-value=0.815, OR=0.8 for paternal transmission; P-value=1, OR=1 for maternal transmission. More... There is no significant difference in the transmission of al...... There is no significant difference in the transmission of alleles to ADHD cases. More... Non-significant
Brookes K, 2006 A/G UNPHASED TDT P-value=0.00302; WHAP TDT P-value=0.010 UNPHASED TDT P-value=0.00302; WHAP TDT P-value=0.010 positive but with opposite allele, significant association w...... positive but with opposite allele, significant association was observed in both UNPHASED and WHAP analyses More... Significant
Park, T. W.,2013 C/T allelic chi-square tests P-value=0.942 (OR=0.98; 95%CI=0.61-...... allelic chi-square tests P-value=0.942 (OR=0.98; 95%CI=0.61-1.57; X2=0.07); genotypic chi-square tests P-value=0.314 (OR=0.48; 95%CI=0.12-1.98; X2=1.01). More... No significant difference was reported in this study. No significant difference was reported in this study. Non-significant
Sheehan K, 2005 C/T allelic TDT P-value=0.095, X2=3.4, OR=1.4; TDT P-...... allelic TDT P-value=0.095, X2=3.4, OR=1.4; TDT P-value=0.04, X2=4.6, OR=1.9 of paternal origin; TDT P-value=0.8, X2=0.1, OR=1.1 of maternal origin More... the trend towards association of allele C in the total sampl...... the trend towards association of allele C in the total sample was stronger for paternal transmissions More... Significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.04, 95% CI=0.77-1.40, P-va...... Meta-analysis model: Random: OR=1.04, 95% CI=0.77-1.40, P-value=0.4; Q-statistic: P-value=0.021, I2=69 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 0)


SNPs in LD with rs1386493 (count: 19) View in gBrowse (chr12:72343287..72382466 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 19)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014