ADHDgene Database

SNP Report

Basic Info

Name	rs1386497 dbSNP Ensembl
Location	chr12:72392290(Fwd)
Variant Alleles	C/A
Ancestral Allele	A
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000333850)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Manor I, 2008			P-value>0.05 P-value>0.05	no significant association no significant association	Non-significant
Sheehan K, 2005	A/C		allelic TDT P-value=0.048, X²=4.2, OR=1.45; TDT P...... allelic TDT P-value=0.048, X²=4.2, OR=1.45; TDT P-value=0.3, X²=0.75, OR=1.4 of paternal origin; TDT P-value=0.06, X²=4.1, OR=1.8 of maternal origin More...	a weaker association was observed a weaker association was observed	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	11(8/3/0)

SNPs in LD with rs1386497 (count: 16) View in gBrowse (chr12:72349290..72404378 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs1386489	intron_variant; nc_transcript_variant	0.913[CEU]; 0.893[TSI]; 0.849[ASW]; 0.846[CHB]; 0.929[MEX]
rs2367899	intron_variant	1.0[CEU]; 0.846[CHB]; 0.927[YRI]
rs990234	intron_variant	0.913[CEU]; 0.848[YRI]
rs1386490	intron_variant; nc_transcript_variant	0.825[CEU]; 0.846[CHB]; 0.853[YRI]
rs7299582	intron_variant; nc_transcript_variant; non_coding_exon_variant	0.913[CEU]; 0.887[TSI]; 0.846[CHB]; 0.925[MEX]; 0.864[YRI]
rs10784944	downstream_gene_variant; intron_variant	0.913[CEU]; 0.893[TSI]; 0.849[ASW]; 0.846[CHB]; 0.925[MEX]; 0.856[YRI]
rs4760749	intron_variant; nc_transcript_variant	0.913[CEU]; 0.846[CHB]
rs7968346	intron_variant; nc_transcript_variant	0.913[CEU]; 0.846[CHB]; 0.807[YRI]
rs10784942	intron_variant; nc_transcript_variant	0.913[CEU]; 0.846[CHB]
rs7300490	intron_variant	1.0[CEU]
rs10748189	intron_variant	0.913[CEU]; 0.846[CHB]; 0.923[YRI]
rs1473473	intron_variant	0.838[CEU]
rs2046582	intron_variant	1.0[CEU]; 0.846[CHB]; 1.0[YRI]
rs4760751	intron_variant	1.0[CEU]; 0.893[TSI]; 0.849[ASW]; 0.846[CHB]; 0.917[CHD]; 0.963[LWK]; 0.929[MEX]; 0.888[MKK]; 1.0[YRI]
rs1843812	intron_variant	1.0[CEU]; 0.853[TSI]; 0.846[CHB]; 0.917[CHD]; 0.929[MEX]; 0.856[YRI]
rs1487281	intron_variant	1.0[CEU]; 0.893[TSI]; 0.849[ASW]; 0.846[CHB]; 0.917[CHD]; 0.8[MEX]