ADHDgene Database

SNP Report

Basic Info

Name	rs1386488 dbSNP Ensembl
Location	Chr12:72344618(Fwd)
Variant Alleles	C/A
Ancestral Allele	A
Functional Annotation	NMD_transcript_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000546576) intron_variant(ENST00000333850; ENST00000546576)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Manor I, 2008			P-value>0.05 P-value>0.05	no significant association no significant association	Non-significant
Sheehan K, 2007		A	TDT test: P-value=0.644, OR=1.2 for full trios; P-value=1.2,...... TDT test: P-value=0.644, OR=1.2 for full trios; P-value=1.2, OR=1 for paternal transmission; P-value=0.557, OR=1.36 for maternal transmission. More...	There is no significant difference in the transmission of al...... There is no significant difference in the transmission of alleles to ADHD cases. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs1386488 (count: 25) View in gBrowse (chr12:72343287..72382466 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6582072	NMD_transcript_variant; intron_variant	1(0/1/0)	0.819[ASW]; 1.0[CEU]; 0.92[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.814[LWK]; 0.944[MEX]; 0.885[MKK]; 0.97[TSI]
rs1843809	NMD_transcript_variant; intron_variant	5(3/2/0)	0.847[CEU]
rs1386492	downstream_gene_variant; intron_variant	1(0/1/0)	0.927[CEU]; 0.843[CHB]; 0.823[JPT]
rs1386493	NMD_transcript_variant; intron_variant	4(2/2/0)	0.813[ASW]; 1.0[CEU]; 0.842[CHB]; 0.846[CHD]; 1.0[GIH]; 1.0[JPT]; 0.835[LWK]; 0.845[MEX]; 0.885[MKK]; 0.97[TSI]; 0.829[YRI]
rs1386496	NMD_transcript_variant; intron_variant	2(0/2/0)	0.847[CEU]
rs1386494	NMD_transcript_variant; intron_variant	1(0/1/0)	0.847[CEU]

rs_ID	Functional Annotation	r²[population]
rs11179003	NMD_transcript_variant; intron_variant	1.0[JPT]
rs1843810	intron_variant	0.85[CEU]; 0.843[CHB]; 0.823[JPT]
rs11179015	downstream_gene_variant; intron_variant	1.0[JPT]
rs10784944	downstream_gene_variant; intron_variant	0.847[CEU]
rs7299582	3_prime_UTR_variant; NMD_transcript_variant; intron_variant	0.847[CEU]
rs11179032	intron_variant	1.0[JPT]
rs12231408	intron_variant	1.0[JPT]
rs12231731	intron_variant	1.0[JPT]
rs11179017	downstream_gene_variant; intron_variant	1.0[JPT]
rs10784942	NMD_transcript_variant; intron_variant	0.847[CEU]
rs11179018	downstream_gene_variant; intron_variant	1.0[JPT]
rs11179004	NMD_transcript_variant; intron_variant	1.0[JPT]
rs10879344	NMD_transcript_variant; intron_variant	1.0[JPT]
rs11179022	intron_variant	1.0[JPT]
rs7968346	NMD_transcript_variant; intron_variant	0.847[CEU]
rs7300641	intron_variant	0.85[CEU]; 0.843[CHB]; 0.804[GIH]; 0.823[JPT]; 0.97[TSI]
rs4760749	NMD_transcript_variant; intron_variant	0.847[CEU]
rs1386489	NMD_transcript_variant; intron_variant	0.847[CEU]
rs7978482	intron_variant	0.85[CEU]; 0.843[CHB]; 0.804[GIH]; 0.823[JPT]; 0.97[TSI]