ADHDgene Database

SNP Report

Basic Info

Name	rs1386488 dbSNP Ensembl
Location	chr12:72344618(Fwd)
Variant Alleles	C/A
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000333850; ENST00000546576) nc_transcript_variant(ENST00000546576)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Manor I, 2008			P-value>0.05 P-value>0.05	no significant association no significant association	Non-significant
Sheehan K, 2007		A	TDT test: P-value=0.644, OR=1.2 for full trios; P-value=1.2,...... TDT test: P-value=0.644, OR=1.2 for full trios; P-value=1.2, OR=1 for paternal transmission; P-value=0.557, OR=1.36 for maternal transmission. More...	There is no significant difference in the transmission of al...... There is no significant difference in the transmission of alleles to ADHD cases. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	11(8/3/0)

SNPs in LD with rs1386488 (count: 19) View in gBrowse (chr12:72343287..72382466 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs12231408	intron_variant	1.0[JPT]
rs10784942	intron_variant; nc_transcript_variant	0.847[CEU]
rs1843810	intron_variant	0.85[CEU]; 0.843[CHB]; 0.823[JPT]
rs11179004	intron_variant; nc_transcript_variant	1.0[JPT]
rs7299582	intron_variant; nc_transcript_variant; non_coding_exon_variant	0.847[CEU]
rs10784944	downstream_gene_variant; intron_variant	0.847[CEU]
rs11179032	intron_variant	1.0[JPT]
rs7968346	intron_variant; nc_transcript_variant	0.847[CEU]
rs7300641	intron_variant	0.85[CEU]; 0.97[TSI]; 0.843[CHB]; 0.823[JPT]; 0.804[GIH]
rs11179003	intron_variant; nc_transcript_variant	1.0[JPT]
rs11179022	intron_variant	1.0[JPT]
rs11179018	downstream_gene_variant; intron_variant	1.0[JPT]
rs7978482	intron_variant	0.85[CEU]; 0.97[TSI]; 0.843[CHB]; 0.823[JPT]; 0.804[GIH]
rs11179015	downstream_gene_variant; intron_variant	1.0[JPT]
rs12231731	intron_variant	1.0[JPT]
rs11179017	downstream_gene_variant; intron_variant	1.0[JPT]
rs4760749	intron_variant; nc_transcript_variant	0.847[CEU]
rs10879344	intron_variant; nc_transcript_variant	1.0[JPT]
rs1386489	intron_variant; nc_transcript_variant	0.847[CEU]