ADHDgene Database

SNP Report

Basic Info

Name	rs1386494 dbSNP Ensembl
Location	Chr12:72352543(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	NMD_transcript_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000546576) intron_variant(ENST00000546576; ENST00000333850)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Manor I, 2008			P-value>0.05 P-value>0.05	no significant association no significant association	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs1386494 (count: 27) View in gBrowse (chr12:72344618..72392290 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs4760814	intron_variant	1(0/1/0)	0.919[CEU]; 1.0[CHB]; 0.843[YRI]
rs1386488	NMD_transcript_variant; intron_variant	2(0/2/0)	0.847[CEU]
rs1386497	intron_variant	2(1/1/0)	0.913[CEU]; 0.846[CHB]
rs6582072	NMD_transcript_variant; intron_variant	1(0/1/0)	0.847[CEU]
rs4760818	intron_variant	2(1/1/0)	0.919[CEU]; 0.823[CHB]
rs1386496	NMD_transcript_variant; intron_variant	2(0/2/0)	1.0[CEU]; 1.0[CHB]
rs1843809	NMD_transcript_variant; intron_variant	5(3/2/0)	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs7963226	intron_variant	1(1/0/0)	0.913[CEU]; 0.846[CHB]; 0.823[YRI]
rs7954568	intron_variant	1(1/0/0)	0.913[CEU]; 1.0[CHB]
rs1386493	NMD_transcript_variant; intron_variant	4(2/2/0)	0.847[CEU]
rs6582081	intron_variant	1(1/0/0)	0.831[CEU]; 0.846[CHB]
rs1007023	intron_variant	1(1/0/0)	0.913[CEU]; 1.0[CHB]

rs_ID	Functional Annotation	r²[population]
rs10784942	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 0.89[YRI]
rs2046582	intron_variant	0.918[CEU]; 1.0[CHB]; 1.0[JPT]
rs7300490	intron_variant	0.919[CEU]
rs7968346	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.895[YRI]
rs11830353	NMD_transcript_variant; intron_variant	1.0[JPT]
rs7299582	3_prime_UTR_variant; NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.823[YRI]
rs10784944	downstream_gene_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.815[YRI]
rs2367899	intron_variant	0.919[CEU]; 1.0[CHB]; 0.837[YRI]
rs4760749	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[YRI]
rs1487281	intron_variant	0.913[CEU]; 1.0[CHB]
rs1386490	NMD_transcript_variant; intron_variant	0.918[CEU]; 1.0[CHB]; 1.0[JPT]; 0.883[YRI]
rs1843812	intron_variant	0.913[CEU]; 1.0[CHB]; 0.815[YRI]
rs1386489	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.875[YRI]
rs10748189	intron_variant	0.842[CEU]; 1.0[CHB]
rs4760751	intron_variant	0.913[CEU]; 1.0[CHB]