ADHDgene Database

SNP Report

Basic Info

Name	rs4760818 dbSNP Ensembl
Location	Chr12:72378923(Fwd)
Variant Alleles	A/T
Ancestral Allele	T
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000333850)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/T		UNPHASED TDT P-value=0.00327; WHAP TDT P-value=0.010 UNPHASED TDT P-value=0.00327; WHAP TDT P-value=0.010	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
Johansson S, 2010			logistic regression P-value=0.08, OR=1.26; meta-analysis P-v...... logistic regression P-value=0.08, OR=1.26; meta-analysis P-value=0.19, OR=0.84 More...	no significant association no significant association	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs4760818 (count: 25) View in gBrowse (chr12:72348698..72405059 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1843809	NMD_transcript_variant; intron_variant	5(3/2/0)	0.913[CEU]; 0.823[CHB]; 0.826[GIH]; 0.865[MEX]
rs1487276	intron_variant	1(1/0/0)	0.838[CEU]
rs4760814	intron_variant	1(0/1/0)	1.0[CEU]; 0.823[CHB]; 0.817[YRI]
rs7954568	intron_variant	1(1/0/0)	1.0[CEU]; 0.823[CHB]; 0.932[YRI]
rs1386494	NMD_transcript_variant; intron_variant	1(0/1/0)	0.919[CEU]; 0.823[CHB]
rs1007023	intron_variant	1(1/0/0)	0.915[ASW]; 1.0[CEU]; 0.823[CHB]; 0.935[GIH]; 0.963[LWK]; 1.0[MEX]; 0.936[MKK]; 1.0[YRI]
rs7963226	intron_variant	1(1/0/0)	0.834[ASW]; 1.0[CEU]; 0.935[GIH]; 0.893[MKK]; 0.856[YRI]
rs1386497	intron_variant	2(1/1/0)	0.919[ASW]; 1.0[CEU]; 0.963[LWK]; 0.928[MEX]; 0.887[MKK]; 1.0[YRI]
rs1386496	NMD_transcript_variant; intron_variant	2(0/2/0)	0.913[CEU]; 0.823[CHB]; 0.935[GIH]; 1.0[MEX]
rs6582081	intron_variant	1(1/0/0)	0.913[CEU]; 0.935[GIH]; 0.858[MEX]

rs_ID	Functional Annotation	r²[population]
rs2367899	intron_variant	1.0[CEU]; 0.823[CHB]; 0.871[YRI]
rs10748189	intron_variant	0.919[CEU]; 0.823[CHB]; 0.928[YRI]
rs2046582	intron_variant	1.0[CEU]; 0.823[CHB]; 1.0[YRI]
rs7300490	intron_variant	1.0[CEU]
rs4760751	intron_variant	0.915[ASW]; 1.0[CEU]; 0.822[CHB]; 1.0[GIH]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[YRI]
rs1487281	intron_variant	0.915[ASW]; 1.0[CEU]; 0.823[CHB]; 0.935[GIH]; 0.865[MEX]
rs1386490	NMD_transcript_variant; intron_variant	0.837[CEU]; 0.822[CHB]; 0.804[YRI]
rs10784944	downstream_gene_variant; intron_variant	0.915[ASW]; 0.913[CEU]; 0.823[CHB]; 0.807[GIH]; 1.0[MEX]; 0.893[MKK]; 0.856[YRI]
rs1843812	intron_variant	0.834[ASW]; 1.0[CEU]; 0.823[CHB]; 0.935[GIH]; 1.0[MEX]; 0.891[MKK]; 0.856[YRI]
rs7968346	NMD_transcript_variant; intron_variant	0.919[CEU]; 0.823[CHB]
rs4760749	NMD_transcript_variant; intron_variant	0.919[CEU]; 0.823[CHB]
rs10784942	NMD_transcript_variant; intron_variant	0.919[CEU]; 0.823[CHB]
rs1386489	NMD_transcript_variant; intron_variant	0.915[ASW]; 0.913[CEU]; 0.823[CHB]; 0.826[GIH]; 1.0[MEX]; 0.813[MKK]
rs990234	intron_variant	0.848[CEU]; 0.857[YRI]
rs7299582	3_prime_UTR_variant; NMD_transcript_variant; intron_variant	0.834[ASW]; 0.913[CEU]; 0.823[CHB]; 0.826[GIH]; 1.0[MEX]; 0.893[MKK]; 0.856[YRI]