ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs40184 dbSNP Ensembl
Location	Chr5:1395077(Fwd)
Variant Alleles	C/T
Ancestral Allele	T
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000453492; ENST00000270349; ENST00000512002)
No. of Studies	7 (significant: 2; non-significant: 5; trend: 0)
Source	Literature-origin

SNP related studies (count: 7)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Nyman ES, 2007			No available information. No available information.	No evidence of association was seen. No evidence of association was seen.	Non-significant
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.0045; WHAP TDT P-value=0.004 UNPHASED TDT P-value=0.0045; WHAP TDT P-value=0.004	significant association was observed in both UNPHASED and WH...... significant association was observed in both UNPHASED and WHAP analyses More...	Significant
Brookes KJ, 2008(a)		C	ST1 TDT P-value=0.005, OR=1.26; ST2 TDT P-value=0.31, OR=1.1...... ST1 TDT P-value=0.005, OR=1.26; ST2 TDT P-value=0.31, OR=1.13; ST1&ST2 TDT P-value=0.005, OR=1.2 More...	not significantly associated in ST2; nominally significant a...... not significantly associated in ST2; nominally significant associations in the combined analysis of ST1 and ST2 More...	Significant
Shang CY, 2011	G/A		G allele FBAT P-value=0.639, Z=0.469 for total sample; A all...... G allele FBAT P-value=0.639, Z=0.469 for total sample; A allele FBAT P-value=0.357, Z=0.921 for combined subtype; G allele FBAT P-value=0.081, Z=1.746 for inattentive subtype More...	no significant associations in the total sample; displayed a...... no significant associations in the total sample; displayed a trend for association in inattentive subtype More...	Non-significant
Gizer IR, 2009			Meta-analysis model: Random: OR=1.06, 95% CI=0.90-1.24, P-va...... Meta-analysis model: Random: OR=1.06, 95% CI=0.90-1.24, P-value=0.249; Q-statistic: P-value=0.141, I²=45 More...	The Fixed effects meta-analysis indicated a trend towards a ...... The Fixed effects meta-analysis indicated a trend towards a modest association between this allele and ADHD, but random effects meta-analysis yielded a nonsignificant result. Moderate but non-significant heterogeneity in effect sizes across studies was observed. An important caveat to these findings is that the results are based on only 4 studies. More...	Non-significant
Genro JP, 2008	A/G		P-value=0.878 for total sample; P-value=0.844 for combined s...... P-value=0.878 for total sample; P-value=0.844 for combined sample More...	no allele was significantly more transmitted than expected no allele was significantly more transmitted than expected	Non-significant
Doyle C, 2009	T:C		TDT P-value=0.56 with T:124 NT:115, OR:1.08 TDT P-value=0.56 with T:124 NT:115, OR:1.08	No statistical significant association was found between thi...... No statistical significant association was found between this marker and ADHD. More...	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources (count: 0)

SNPs in LD with rs40184 (count: 0) View in gBrowse (chr5:1395077..1395077 )