ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs6311 dbSNP Ensembl
Location chr13:47471478(Fwd)
Variant Alleles C/T
Ancestral Allele C
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000378688; ENST00000542664; ENST00000543956)
No. of Studies 5 (significant: 1; non-significant: 4; trend: 0)
Source Literature-origin

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Gizer IR, 2009 Meta-analysis model: Fixed: OR=1.04, 95% CI=0.94-1.14, two-t...... Meta-analysis model: Fixed: OR=1.04, 95% CI=0.94-1.14, two-tailed P-value=0.449; Q-statistic: P-value=0.705, I2=0 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Bobb AJ, 2005 allelic TDT P-value=0.96, OR=1.01 in case-control analysis; ...... allelic TDT P-value=0.96, OR=1.01 in case-control analysis; allelic TDT P-value=0.67, RR=0.91 in family-based analysis More... non-significant association non-significant association Non-significant
Pazvantoglu, O.,2013 A/G genotype: (AA vs AG vs GG ), chi-square tests, P-value=0.117...... genotype: (AA vs AG vs GG ), chi-square tests, P-value=0.117, X2=7.379; allele: chi-square tests, P-value=0.042, X2=6.339 among the groups; allelic P-value = 0.012, X2=6.315, df = 1, between the ADHD and the HC groups; Presence of the A allele (AA + AG): P-value=0.028, X2=7.187, df = 2 among the groups; P-value = 0.007, X2 =7.201, df = 1, between the ADHD and HC groups; Presence of the G allele (GG + AG); X2 =1.813, P-value =0.014 among the groups More... A significant difference was determined between the groups f...... A significant difference was determined between the groups for 5-HT2A (rs6311). 5-HT2A (rs6311) exhibited a significant difference between the ADHD and HC groups. There were no differences in allele frequencies of 5-HT2A (rs6311) between the ADHD and Non-ADHD groups, and the Non-ADHD and HC groups, after the Bonferroni correction. The 5-HT2A (rs6311) G allele exhibited no significant difference among the groups, while A allele presence was significantly higher in the ADHD group than in the HC group. There were no differences in rates of A allele presence between the ADHD and Non-ADHD groups, and the Non-ADHD and HC groups, after the Bonferroni correction. More... Significant
Heiser P, 2007 G/A allelic PDT P-value=0.40 allelic PDT P-value=0.40 showed no statistically significant preferential transmissio...... showed no statistically significant preferential transmission of any allele More... Non-significant
Brookes K, 2006 A/G UNPHASED TDT P-value=0.183; WHAP TDT P-value=0.321 UNPHASED TDT P-value=0.183; WHAP TDT P-value=0.321 no significant association was observed no significant association was observed Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 0)


SNPs in LD with rs6311 (count: 23) View in gBrowse (chr13:47439371..47523624 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 23)