ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs1108580 dbSNP Ensembl
Location chr9:136505114(Fwd)
Variant Alleles A/G
Ancestral Allele G
Functional Annotation intron_variant; splice_region_variant; synonymous_variant.
Consequence to Transcript intron_variant(ENST00000263611)
splice_region_variant(ENST00000393056)
synonymous_variant(ENST00000393056)
No. of Studies 6 (significant: 1; non-significant: 5; trend: 0)
Source Literature-origin

SNP related studies (count: 6)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Bhaduri N, 2010 G:A allelic frequencies P-value=0.43, X2=0.6; genotyp...... allelic frequencies P-value=0.43, X2=0.6; genotypic frequencies P-value=0.64, X2=0.91; HHRR P-value=0.36, OR=1.27, X2=0.84, TDT P-value=0.37, RR=1.26, X2=0.81 for overall transmission; HHRR P-value=0.46, OR=1.32, X2=0.55, TDT P-value=0.45, RR=1.33, X2=0.57 for paternal transmission; HHRR P-value=0.58, OR=1.23, X2=0.34, TDT P-value=0.6, RR=1.2, X2=0.27 for maternal transmission More... no significant association with ADHD no significant association with ADHD Non-significant
Bhaduri N, 2006 (b) allelic HHRR P-value=0.68, X2=0.17, RR=1.06 (for ...... allelic HHRR P-value=0.68, X2=0.17, RR=1.06 (for A1); allelic TDT P-value=0.54, X2=0.38, RR=0.95 (for A2) More... HHRR analysis suggested lack of significant increase in the ...... HHRR analysis suggested lack of significant increase in the transmission of the polymorphism in ADHD subjects and TDT revealed a minor increase in transmission of the 'g' allele in the probands More... Non-significant
Kwon, H. J.,2013 A/G allelic chi-square tests, P-value=0.149 (OR=1.47; 95%CI=0.87...... allelic chi-square tests, P-value=0.149 (OR=1.47; 95%CI=0.87-2.48; X2=1.44); genotypic chi-square tests, P-value=0.170 (OR=1.50; 95%CI=0.84-2.67; X2=1.37). More... No signi?cant correlation was found in this study. No signi?cant correlation was found in this study. Non-significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.09, 95% CI=0.93-1.28, P-va...... Meta-analysis model: Random: OR=1.09, 95% CI=0.93-1.28, P-value=0.145; Q-statistic: P-value=0.284, I2=20 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Das M, 2011 G/A ETDT P-value=0.25, X2(1df)=1.33, RR=1; allelic fr...... ETDT P-value=0.25, X2(1df)=1.33, RR=1; allelic frequencies COCAPHASE P-value=0.08, X2=3.08 for G; ETDT P-value=0.25, X2(1df)=1.33, RR=0.75; allelic frequencies COCAPHASE P-value=0.08, X2=3.08 for A More... no significant association was noticed by case-control or fa...... no significant association was noticed by case-control or family-based association analyses More... Non-significant
Guan L, 2009 single SNP association analyses: Nominal P-value=0.033, Empi...... single SNP association analyses: Nominal P-value=0.033, Empirical P-value=0.433 for ADHD-I More... non-significant for ADHD, but achieve nominal significance f...... non-significant for ADHD, but achieve nominal significance for ADHD-I More... Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 0)


SNPs in LD with rs1108580 (count: 5) View in gBrowse (chr9:136503256..136511385 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 5)