ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6347 dbSNP Ensembl
Location	Chr5:1411412(Fwd)
Variant Alleles	T/C
Ancestral Allele	C
Functional Annotation	downstream_gene_variant; synonymous_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000511750; ENST00000513308) synonymous_variant(ENST00000453492; ENST00000270349)
No. of Studies	6 (significant: 0; non-significant: 6; trend: 0)
Source	Literature-origin

SNP related studies (count: 6)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Bobb AJ, 2005			allelic TDT P-value=0.17, OR=1.22 in case-control analysis; ...... allelic TDT P-value=0.17, OR=1.22 in case-control analysis; allelic TDT P-value=0.27, RR=0.73 in family-based analysis More...	non-significant association non-significant association	Non-significant
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.391; WHAP TDT P-value=0.106 UNPHASED TDT P-value=0.391; WHAP TDT P-value=0.106	significant association was observed with A allele in WHAP a...... significant association was observed with A allele in WHAP analysis More...	Non-significant
Gizer IR, 2009			Meta-analysis model: Random: OR=1.08, 95% CI=0.94-1.22, two-...... Meta-analysis model: Random: OR=1.08, 95% CI=0.94-1.22, two-tailed P-value=0.272; Q-statistic: P-value=0.325, I²=14 More...	no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More...	Non-significant
Feng Y, 2005(a)	G/A		allelic TDT P-value (2-sided)=0.057, X²=3.612 allelic TDT P-value (2-sided)=0.057, X²=3.612	there was a trend for biased transmission there was a trend for biased transmission	Non-significant
Genro JP, 2008	A/G		P-value=0.86 for total sample; P-value=0.911 for combined sa...... P-value=0.86 for total sample; P-value=0.911 for combined sample More...	no allele was significantly more transmitted than expected no allele was significantly more transmitted than expected	Non-significant
Friedel S, 2007	A/G	A	FAMHAP P-value=1 in single marker association analysis FAMHAP P-value=1 in single marker association analysis	No association was found with ADHD No association was found with ADHD	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	5p15.3	68(42/25/1)

Genes from other sources (count: 0)

SNPs in LD with rs6347 (count: 4) View in gBrowse (chr5:1394815..1411412 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 2)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1042098	3_prime_UTR_variant	2(1/1/0)	1.0[JPT]
rs11133767	intron_variant; upstream_gene_variant	1(0/1/0)	1.0[JPT]

rs_ID	Functional Annotation	r²[population]
rs3776512	intron_variant	0.929[MEX]
rs3776511	intron_variant	0.929[MEX]

SNP Report

Literature-origin genes (count: 1)

Genes from other sources (count: 0)

Literature-origin SNPs (count: 2)

LD-proxies (count: 2)