Cheuk DK, 2006(c)16676224
||Cheuk D. K. and Wong V. (2006) "Meta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder." Behav Genet, 36(5): 651-9.
||Candidate association study
||They perform a meta-analysis of previous studies to assess the overall magnitude and significance of the association. Family-based and case-control studies of the association between the COMT gene polymorphism and ADHD were searched systematically and comprehensively. Odds ratios (OR) of association were pooled by the fixed effects model if no significant heterogeneity was present among different studies. Subgroup analysis by gender and ADHD subtypes were also performed. Eleven family-based and two case-control studies were identified. After pooling the results, no significant association between the COMT Val158/108Met polymorphism and ADHD was found. There was also no significant association when the results were stratified by gender or ADHD subtype. There was no significant statistical heterogeneity although clinical heterogeneity was present in the studies, especially the ethnicity of subjects. Sensitivity analysis demonstrated absence of undue influence of any single study. Standard regression analysis showed no significant publication bias.
SNPs reported by this study: 1
Genes reported by this study: 1