ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs4818 dbSNP Ensembl
Location	chr22:19951207(Fwd)
Variant Alleles	C/G/T
Ancestral Allele	G
Functional Annotation	downstream_gene_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000467943) nc_transcript_variant(ENST00000493893) NMD_transcript_variant(ENST00000207636) non_coding_exon_variant(ENST00000493893) synonymous_variant(ENST00000207636; ENST00000361682; ENST00000403184; ENST00000403710; ENST00000406520; ENST00000407537; ENST00000412786; ENST00000449653) upstream_gene_variant(ENST00000428707; ENST00000585066)
No. of Studies	3 (significant: 2; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Pazvantoglu, O.,2013	G/C		genotype: (GG vs GC vs CC), chi-square tests, P-value=0.372,...... genotype: (GG vs GC vs CC), chi-square tests, P-value=0.372, X²=4.258; allele: chi-square tests, P-value=0.174, X²=3.494 among the groups More...	No significant difference was observed between the groups in...... No significant difference was observed between the groups in terms of allele frequencies for COMT (rs4818). More...	Non-significant
Michaelovsky E, 2008	C/G		P-value=0.005, X²(1)=7.77 P-value=0.005, X²(1)=7.77	showed significant association with ADHD showed significant association with ADHD	Significant
Halleland H, 2009	G/C		Single marker test: P-value=0.42 (OR=1.09 [0.89-1.33]); Quan...... Single marker test: P-value=0.42 (OR=1.09 [0.89-1.33]); Quantitative linear regression analysis: P-value=0.02 (beta=0.73) for hyperactivity subscale; P-value=0.34 (beta=-0.29) for inattention subscale; P-value=0.42 (beta=0.44) for ASRS total More...	no association with ADHD, but tendenial association with hyp...... no association with ADHD, but tendenial association with hyperactivity/impulsivity. More...	Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Genes from other sources (count: 1)

SNPs in LD with rs4818 (count: 0) View in gBrowse (chr22:19951207..19951207 )