ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs4818 dbSNP Ensembl
Location chr22:19951207(Fwd)
Variant Alleles C/G/T
Ancestral Allele G
Functional Annotation downstream_gene_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000467943)
nc_transcript_variant(ENST00000493893)
NMD_transcript_variant(ENST00000207636)
non_coding_exon_variant(ENST00000493893)
synonymous_variant(ENST00000207636; ENST00000361682; ENST00000403184; ENST00000403710; ENST00000406520; ENST00000407537; ENST00000412786; ENST00000449653)
upstream_gene_variant(ENST00000428707; ENST00000585066)
No. of Studies 3 (significant: 2; non-significant: 1; trend: 0)
Source Literature-origin

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Pazvantoglu, O.,2013 G/C genotype: (GG vs GC vs CC), chi-square tests, P-value=0.372,...... genotype: (GG vs GC vs CC), chi-square tests, P-value=0.372, X2=4.258; allele: chi-square tests, P-value=0.174, X2=3.494 among the groups More... No significant difference was observed between the groups in...... No significant difference was observed between the groups in terms of allele frequencies for COMT (rs4818). More... Non-significant
Michaelovsky E, 2008 C/G P-value=0.005, X2(1)=7.77 P-value=0.005, X2(1)=7.77 showed significant association with ADHD showed significant association with ADHD Significant
Halleland H, 2009 G/C Single marker test: P-value=0.42 (OR=1.09 [0.89-1.33]); Quan...... Single marker test: P-value=0.42 (OR=1.09 [0.89-1.33]); Quantitative linear regression analysis: P-value=0.02 (beta=0.73) for hyperactivity subscale; P-value=0.34 (beta=-0.29) for inattention subscale; P-value=0.42 (beta=0.44) for ASRS total More... no association with ADHD, but tendenial association with hyp...... no association with ADHD, but tendenial association with hyperactivity/impulsivity. More... Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 1)


SNPs in LD with rs4818 (count: 0) View in gBrowse (chr22:19951207..19951207 )