ADHDgene Database

SNP Report

Basic Info

Name	rs740603 dbSNP Ensembl
Location	chr22:19945177(Fwd)
Variant Alleles	A/G
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000207636; ENST00000361682; ENST00000403184; ENST00000403710; ENST00000406520; ENST00000407537; ENST00000412786; ENST00000467943) nc_transcript_variant(ENST00000467943) NMD_transcript_variant(ENST00000207636) upstream_gene_variant(ENST00000449653)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Nyman ES, 2007			No available information. No available information.	No evidence of association was seen. No evidence of association was seen.	Non-significant
Hawi, Z., 2012	G:A	A	P-value=0.4378, X²=0.6, OR=1.12, 95% CI=0.85-1.47 P-value=0.4378, X²=0.6, OR=1.12, 95% CI=0.85-1.47	The marker did not show significant association with ADHD. The marker did not show significant association with ADHD.	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
COMT	catechol-O-methyltransferase	22q11.21	29(7/22/0)

SNPs in LD with rs740603 (count: 4) View in gBrowse (chr22:19937638..19950763 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs5993883	intron_variant; nc_transcript_variant; upstream_gene_variant	0.902[JPT]
rs2239393	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	0.819[CHB]
rs740601	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	0.819[CHB]
rs4646312	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.819[CHB]