ADHDgene Database

SNP Report

Basic Info

Name	rs4633 dbSNP Ensembl
Location	Chr22:19950235(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	NMD_transcript_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000207636) nc_transcript_variant(ENST00000467943) non_coding_exon_variant(ENST00000467943) synonymous_variant(ENST00000407537; ENST00000406520; ENST00000403184; ENST00000403710; ENST00000412786; ENST00000207636; ENST00000361682; ENST00000449653) upstream_gene_variant(ENST00000493893; ENST00000585066; ENST00000428707)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Michaelovsky E, 2008	C/T		P-value=0.005, X²(1)=7.77 P-value=0.005, X²(1)=7.77	showed significant association with ADHD showed significant association with ADHD	Significant
Halleland H, 2009	C//T		Single marker test: P-value=0.66 (OR=1.05 [0.86-1.27]) \| Qua...... Single marker test: P-value=0.66 (OR=1.05 [0.86-1.27]) \| Quantitative linear regression analysis: P-value=0.06 (beta=0.55) for hyperactivity subscale; P-value=0.30 (beta=-0.30) for inattention subscale; P-value=0.65 (beta=0.24) for ASRS total More...	no association with ADHD, but tendenial association with hyp...... no association with ADHD, but tendenial association with hyperactivity/impulsivity. More...	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
COMT	catechol-O-methyltransferase	22q11.21	25(5/20/0)

Approved Symbol	Approved Name	Location
MIR4761	microRNA 4761	22

SNPs in LD with rs4633 (count: 4) View in gBrowse (chr22:19948863..19951271 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.


rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]
rs4680	NMD_transcript_variant; downstream_gene_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	22(4/18/0)	1.0[CEU]; 0.936[CHB]; 0.944[CHD]; 0.954[GIH]; 0.935[JPT]; 0.88[LWK]; 0.911[MEX]; 0.805[MKK]; 0.977[TSI]

rs_ID	Functional Annotation	r²[population]
rs2239393	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.834[TSI]
rs740601	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.834[TSI]
rs165656	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.87[GIH]; 1.0[JPT]; 1.0[MEX]; 0.955[TSI]