ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name COMT_158G/A
Type point mutation
Location at codon 158
Related Gene COMT
No. of Study 2 (significant: 1; non-significant 1; trend: 0)

Variant related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Yatsuga, C.,2013 G/A X2 = 7.13, df=1, chi-square test, P-value < 0.01 X2 = 7.13, df=1, chi-square test, P-value < 0.01 The occurrence of the COMT Val/Val genotype was significantl...... The occurrence of the COMT Val/Val genotype was significantly higher in children with ADHD (X2(1)=7.13, p<0.01). However, there was no significant difference in the Val/Val genotype according to disorder, and WISC and ADHD rating scale scores, after correcting for the interaction between disorder and COMT genotype. More... Significant
Payton A, 2001 G/A allelic TDT P-value=0.92 allelic TDT P-value=0.92 there was no evidence of preferential transmission of any ma...... there was no evidence of preferential transmission of any marker allele More... Non-significant