ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ITK
Symbol Alias	EMT, PSCTK2, LYK
Approved Name	IL2-inducible T-cell kinase
Location	5q31-q32
Position	chr5:156569944-156682201, +
External Links	HGNC: 6171 Entrez Gene: 3702 UCSC: uc003lwo.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5q33.3	chr5:155700000-159900000	1 (1/0/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050852	T cell receptor signaling pathway	Biological Process		21
GO:0042110	T cell activation	Biological Process	TAS[12186560]	8
GO:0046872	metal ion binding	Molecular Function		170
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IDA[12186560]	6
GO:0002250	adaptive immune response	Biological Process		5
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function	IPI[19807924]	910
GO:0001865	NK T cell differentiation	Biological Process		1
GO:0001816	cytokine production	Biological Process		5
GO:0032609	interferon-gamma production	Biological Process		2
GO:0007202	activation of phospholipase C activity	Biological Process		12
GO:0035556	intracellular signal transduction	Biological Process		44
GO:0032633	interleukin-4 production	Biological Process		1
GO:0005829	cytosol	Cellular Component		447
GO:0005543	phospholipid binding	Molecular Function		61
GO:0007165	signal transduction	Biological Process	TAS[8364206]	171
GO:0006968	cellular defense response	Biological Process	TAS[8364206]	12

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04670	Leukocyte transendothelial migration	22	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...
hsa04660	T cell receptor signaling pathway	19	Activation of T lymphocytes is a key event for an efficient ...... Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. More...

Genes shared at least 5 GO terms with ITK (count: 10)

Gene Symbol	Pathway Count	Pathway List
PIK3CG	6	T cell activation; adaptive immune response; ATP binding; protein binding; cytokine production; cytosol;
ADCY4	6	metal ion binding; ATP binding; protein binding; activation of phospholipase C activity; intracellular signal transduction; signal transduction;
PRKD1	6	metal ion binding; ATP binding; protein binding; cytosol; phospholipid binding; signal transduction;
ROCK2	6	metal ion binding; ATP binding; protein binding; intracellular signal transduction; cytosol; phospholipid binding;
ADRBK1	6	ATP binding; protein binding; activation of phospholipase C activity; cytosol; phospholipid binding; signal transduction;
MAPK1	5	T cell receptor signaling pathway; ATP binding; protein binding; cytosol; signal transduction;
PRKAA1	5	metal ion binding; ATP binding; protein binding; cytosol; signal transduction;
SYK	5	non-membrane spanning protein tyrosine kinase activity; adaptive immune response; ATP binding; protein binding; cytosol;
PRKCB	5	ATP binding; protein binding; intracellular signal transduction; cytosol; signal transduction;
RASA1	5	protein binding; intracellular signal transduction; cytosol; phospholipid binding; signal transduction;

Genes shared at least 2 KEGG pathways with ITK (count: 11)

Gene Symbol	Pathway Count	Pathway List
PIK3CG	3	Chemokine signaling pathway; Leukocyte transendothelial migration; T cell receptor signaling pathway;
PIK3R1	3	Chemokine signaling pathway; Leukocyte transendothelial migration; T cell receptor signaling pathway;
BCAR1	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
CXCL12	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
GSK3B	2	Chemokine signaling pathway; T cell receptor signaling pathway;
MAPK1	2	Chemokine signaling pathway; T cell receptor signaling pathway;
MAPK3	2	Chemokine signaling pathway; T cell receptor signaling pathway;
PAK1	2	Chemokine signaling pathway; T cell receptor signaling pathway;
PRKCB	2	Chemokine signaling pathway; Leukocyte transendothelial migration;
RELA	2	Chemokine signaling pathway; T cell receptor signaling pathway;
ROCK2	2	Chemokine signaling pathway; Leukocyte transendothelial migration;

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Region: chr5:156569944..156682201 View in gBrowse