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KEGG Pathway Report
Basic Info
| ID | hsa04660 |
|---|---|
| Name | T cell receptor signaling pathway |
| Description | Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 18)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 14q11.2 | Mapped by significant region |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 11q13-q14 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 18q21 | Mapped by significant region |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 11q23 | Mapped by significant region |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 11q23.3-qter | Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 11q23 | Mapped by significant region |
| NCK1 | NCK adaptor protein 1 | 3q21 | Mapped by PBA pathway |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 11q23 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| NCK2 | NCK adaptor protein 2 | 2q12 | Mapped by PBA pathway |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| ITK | IL2-inducible T-cell kinase | 5q31-q32 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta | 9q31 | Mapped by significant region |
| PAK7 | p21 protein (Cdc42/Rac)-activated kinase 7 | 20p12 | Mapped by CNV |