ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRKAB2
Approved Name	protein kinase, AMP-activated, beta 2 non-catalytic subunit
Name Alias	"AMPK beta 2"
Location	1q21.2
Position	chr1:146626685-146644129, -1
External Links	HGNC: 9379 Entrez Gene: 5565 Ensembl: ENSG00000131791 UCSC: uc001epe.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_2	chr1:144943150-146293282 (NCBI36 / hg18)	1350133	1q21.1	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044255	cellular lipid metabolic process	biological process	TAS	33
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0004679	AMP-activated protein kinase activity	molecular function	IDA	3
GO:0006112	energy reserve metabolic process	biological process	TAS	31
GO:0031588	AMP-activated protein kinase complex	cellular component	IDA[17851531]	4
GO:0042802	identical protein binding	molecular function	IPI	77
GO:0005515	protein binding	molecular function	IPI	1015
GO:0007050	cell cycle arrest	biological process	TAS	28
GO:0042304	regulation of fatty acid biosynthetic process	biological process	TAS	3
GO:0046320	regulation of fatty acid oxidation	biological process	TAS	6
GO:0007165	signal transduction	biological process	TAS[9575201]	189
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0006633	fatty acid biosynthetic process	biological process	IEA	16
GO:0008286	insulin receptor signaling pathway	biological process	TAS	37
GO:0005829	cytosol	cellular component	TAS	485
GO:0006853	carnitine shuttle	biological process	TAS	3

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04910	Insulin signaling pathway	29
hsa04920	Adipocytokine signaling pathway	9

Genes shared at least 5 GO terms with PRKAB2 (count: 10)

Gene Symbol	Pathway Count	Pathway List
PRKAG2	12	cellular lipid metabolic process; small molecule metabolic process; energy reserve metabolic process; AMP-activated protein kinase complex; cell cycle arrest; regulation of fatty acid biosynthetic process; regulation of fatty acid oxidation; nucleoplasm; fatty acid biosynthetic process; insulin receptor signaling pathway; cytosol; carnitine shuttle;
STK11	9	small molecule metabolic process; energy reserve metabolic process; identical protein binding; protein binding; cell cycle arrest; regulation of fatty acid biosynthetic process; regulation of fatty acid oxidation; insulin receptor signaling pathway; cytosol;
PRKAA1	9	AMP-activated protein kinase activity; AMP-activated protein kinase complex; protein binding; cell cycle arrest; regulation of fatty acid oxidation; signal transduction; fatty acid biosynthetic process; insulin receptor signaling pathway; cytosol;
PRKAG3	7	AMP-activated protein kinase activity; AMP-activated protein kinase complex; cell cycle arrest; regulation of fatty acid oxidation; fatty acid biosynthetic process; insulin receptor signaling pathway; cytosol;
ACACA	6	cellular lipid metabolic process; small molecule metabolic process; energy reserve metabolic process; protein binding; fatty acid biosynthetic process; cytosol;
CREBBP	5	cellular lipid metabolic process; small molecule metabolic process; protein binding; signal transduction; nucleoplasm;
CPT1A	5	cellular lipid metabolic process; small molecule metabolic process; identical protein binding; regulation of fatty acid oxidation; carnitine shuttle;
PRKD1	5	small molecule metabolic process; identical protein binding; protein binding; signal transduction; cytosol;
TXN	5	small molecule metabolic process; protein binding; signal transduction; nucleoplasm; cytosol;
MAPK1	5	protein binding; signal transduction; nucleoplasm; insulin receptor signaling pathway; cytosol;

Genes shared at least 2 KEGG pathways with PRKAB2 (count: 4)

Gene Symbol	Pathway Count	Pathway List
PRKAG3	2	Insulin signaling pathway; Adipocytokine signaling pathway;
PRKAA1	2	Insulin signaling pathway; Adipocytokine signaling pathway;
MAPK9	2	Insulin signaling pathway; Adipocytokine signaling pathway;
PRKAG2	2	Insulin signaling pathway; Adipocytokine signaling pathway;

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Region: chr1:146626685..146644129 View in gBrowse