ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MARK2
Previous Symbol	EMK1
Symbol Alias	PAR-1, Par1b
Approved Name	MAP/microtubule affinity-regulating kinase 2
Previous Name	ELKL motif kinase
Name Alias	ELKL motif kinase 1, "serine/threonine kinase", "protein-serine/threonine kinase", "Ser/Thr protein kinase PAR-1B"
Location	11q13.1
Position	chr11:63606400-63678492, +
External Links	HGNC: 3332 Entrez Gene: 2011 Ensembl: ENSG00000072518 UCSC: uc001nxw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS[8274451]	61
GO:0001764	neuron migration	Biological Process		21
GO:0000287	magnesium ion binding	Molecular Function	IDA[14976552]	28
GO:0005886	plasma membrane	Cellular Component		772
GO:0005634	nucleus	Cellular Component		770
GO:0005524	ATP binding	Molecular Function	IDA[14976552]	228
GO:0005515	protein binding	Molecular Function	IPI[19615732]	910
GO:0007243	intracellular protein kinase cascade	Biological Process	IDA[14976552]	19
GO:0008289	lipid binding	Molecular Function		23
GO:0006468	protein phosphorylation	Biological Process	IDA[14976552]; NAS[8274451]	53
GO:0006979	response to oxidative stress	Biological Process	IEP[16551573]	17
GO:0016055	Wnt receptor signaling pathway	Biological Process		20
GO:0030010	establishment of cell polarity	Biological Process	IDA[12429843]; TAS[16775013]	4
GO:0010976	positive regulation of neuron projection development	Biological Process	IDA[12429843]	9
GO:0016020	membrane	Cellular Component	IMP[14976552]	139
GO:0046777	protein autophosphorylation	Biological Process		23
GO:0050321	tau-protein kinase activity	Molecular Function		5
GO:0045180	basal cortex	Cellular Component		1
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	Biological Process	IDA[15324659]	2
GO:0050770	regulation of axonogenesis	Biological Process		6

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MARK2 (count: 37)

Gene Symbol	Pathway Count	Pathway List
GSK3B	8	protein serine/threonine kinase activity; plasma membrane; nucleus; ATP binding; protein binding; protein phosphorylation; establishment of cell polarity; tau-protein kinase activity;
PRKD1	8	protein serine/threonine kinase activity; plasma membrane; nucleus; ATP binding; protein binding; intracellular protein kinase cascade; positive regulation of neuron projection development; protein autophosphorylation;
SIK2	8	protein serine/threonine kinase activity; magnesium ion binding; nucleus; ATP binding; protein binding; intracellular protein kinase cascade; protein phosphorylation; protein autophosphorylation;
NEK6	7	protein serine/threonine kinase activity; magnesium ion binding; nucleus; ATP binding; protein binding; protein phosphorylation; protein autophosphorylation;
RPS6KA4	7	protein serine/threonine kinase activity; magnesium ion binding; nucleus; ATP binding; protein binding; intracellular protein kinase cascade; protein phosphorylation;
ILK	6	protein serine/threonine kinase activity; plasma membrane; ATP binding; protein binding; protein phosphorylation; establishment or maintenance of epithelial cell apical/basal polarity;
LATS1	6	protein serine/threonine kinase activity; magnesium ion binding; ATP binding; protein binding; protein phosphorylation; regulation of cytoskeleton organization;
LATS2	6	protein serine/threonine kinase activity; nucleus; ATP binding; protein binding; intracellular protein kinase cascade; protein phosphorylation;
PAK1	6	protein serine/threonine kinase activity; plasma membrane; ATP binding; protein binding; protein phosphorylation; protein autophosphorylation;
PRKCB	6	protein serine/threonine kinase activity; plasma membrane; nucleus; ATP binding; protein binding; protein phosphorylation;
ROCK2	6	protein serine/threonine kinase activity; plasma membrane; nucleus; ATP binding; protein binding; protein phosphorylation;
STK36	6	protein serine/threonine kinase activity; magnesium ion binding; nucleus; ATP binding; protein binding; protein phosphorylation;
TSSK2	6	protein serine/threonine kinase activity; magnesium ion binding; ATP binding; protein binding; protein phosphorylation; protein autophosphorylation;
WNK2	6	protein serine/threonine kinase activity; plasma membrane; ATP binding; intracellular protein kinase cascade; protein phosphorylation; protein autophosphorylation;
ERBB2	6	plasma membrane; nucleus; ATP binding; protein binding; protein phosphorylation; protein autophosphorylation;
PRKAA1	6	nucleus; ATP binding; protein binding; protein phosphorylation; Wnt receptor signaling pathway; tau-protein kinase activity;
BMPR1B	5	protein serine/threonine kinase activity; plasma membrane; ATP binding; protein binding; protein phosphorylation;
CDC42BPG	5	protein serine/threonine kinase activity; magnesium ion binding; ATP binding; protein binding; protein phosphorylation;
CSNK1E	5	protein serine/threonine kinase activity; nucleus; ATP binding; protein binding; protein phosphorylation;
MAP3K11	5	protein serine/threonine kinase activity; ATP binding; protein binding; protein phosphorylation; protein autophosphorylation;
MAP4K2	5	protein serine/threonine kinase activity; ATP binding; protein binding; intracellular protein kinase cascade; protein phosphorylation;
MAPK1	5	protein serine/threonine kinase activity; nucleus; ATP binding; protein binding; regulation of cytoskeleton organization;
MARK4	5	protein serine/threonine kinase activity; ATP binding; protein binding; protein phosphorylation; tau-protein kinase activity;
PIK3CG	5	protein serine/threonine kinase activity; plasma membrane; ATP binding; protein binding; membrane;
PLK1	5	protein serine/threonine kinase activity; nucleus; ATP binding; protein binding; protein phosphorylation;
SGK1	5	protein serine/threonine kinase activity; plasma membrane; nucleus; ATP binding; protein phosphorylation;
SIK3	5	protein serine/threonine kinase activity; magnesium ion binding; ATP binding; protein binding; protein phosphorylation;
SMG1	5	protein serine/threonine kinase activity; nucleus; ATP binding; protein binding; protein autophosphorylation;
STK16	5	protein serine/threonine kinase activity; ATP binding; protein binding; membrane; protein autophosphorylation;
TGFBR1	5	protein serine/threonine kinase activity; plasma membrane; ATP binding; protein binding; protein phosphorylation;
TSSK4	5	protein serine/threonine kinase activity; magnesium ion binding; ATP binding; protein binding; protein phosphorylation;
PRKG1	5	neuron migration; plasma membrane; ATP binding; protein binding; protein phosphorylation;
ACHE	5	plasma membrane; nucleus; protein binding; membrane; regulation of axonogenesis;
FLT4	5	plasma membrane; nucleus; ATP binding; protein binding; protein autophosphorylation;
FRK	5	plasma membrane; nucleus; ATP binding; protein binding; protein phosphorylation;
SYK	5	plasma membrane; ATP binding; protein binding; protein phosphorylation; protein autophosphorylation;
MAPK3	5	nucleus; ATP binding; protein binding; protein phosphorylation; regulation of cytoskeleton organization;

Genes shared at least 2 KEGG pathways with MARK2 (count: 0)

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Region: chr11:63606400..63678492 View in gBrowse