ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	WNK2
Previous Symbol	SDCCAG43, PRKWNK2
Symbol Alias	NY-CO-43, KIAA1760
Approved Name	WNK lysine deficient protein kinase 2
Previous Name	serologically defined colon cancer antigen 43
Location	9q22.3
Position	chr9:95947198-96082854, +
External Links	HGNC: 14542 Entrez Gene: 65268 Ensembl: ENSG00000165238 UCSC: uc004atj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0006468	protein phosphorylation	Biological Process		53
GO:0005524	ATP binding	Molecular Function		228
GO:0005737	cytoplasm	Cellular Component	IDA[17667937]	690
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:2000651	positive regulation of sodium ion transmembrane transporter activity	Biological Process		2
GO:2000021	regulation of ion homeostasis	Biological Process		2
GO:0070373	negative regulation of ERK1 and ERK2 cascade	Biological Process	IMP[17667937]	5
GO:0046777	protein autophosphorylation	Biological Process	IDA[17667937]	23
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP[17667937]	59
GO:0007243	intracellular protein kinase cascade	Biological Process		19

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with WNK2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
MARK2	6	plasma membrane; protein phosphorylation; ATP binding; protein serine/threonine kinase activity; protein autophosphorylation; intracellular protein kinase cascade;
PAK1	6	plasma membrane; protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity; protein autophosphorylation;
PRKD1	6	plasma membrane; ATP binding; cytoplasm; protein serine/threonine kinase activity; protein autophosphorylation; intracellular protein kinase cascade;
SIK2	6	protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity; protein autophosphorylation; intracellular protein kinase cascade;
FRK	5	plasma membrane; protein phosphorylation; ATP binding; cytoplasm; negative regulation of cell proliferation;
GSK3B	5	plasma membrane; protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity;
ILK	5	plasma membrane; protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity;
PRKCB	5	plasma membrane; protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity;
MAP3K11	5	protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity; protein autophosphorylation;
NEK6	5	protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity; protein autophosphorylation;
RPS6KA4	5	protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity; intracellular protein kinase cascade;
TSSK2	5	protein phosphorylation; ATP binding; cytoplasm; protein serine/threonine kinase activity; protein autophosphorylation;

Genes shared at least 2 KEGG pathways with WNK2 (count: 0)

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Region: chr9:95947198..96082854 View in gBrowse