ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	AURKC
Previous Symbol	STK13
Symbol Alias	AurC, ARK3
Approved Name	aurora kinase C
Previous Name	serine/threonine kinase 13 (aurora/IPL1-like)
Location	19q13.3-qter
Position	chr19:57742377-57746916, +
External Links	HGNC: 11391 Entrez Gene: 6795 Ensembl: ENSG00000105146 UCSC: uc002qoe.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs7252399	Chr19:57748905(Fwd)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000775	chromosome, centromeric region	Cellular Component		9
GO:0071777	positive regulation of cell cycle cytokinesis	Biological Process	TAS[19774610]	3
GO:0051256	spindle midzone assembly involved in mitosis	Biological Process	TAS[19774610]	2
GO:0016570	histone modification	Biological Process	TAS[19774610]	1
GO:0030496	midbody	Cellular Component	IDA[15670791]; TAS[19774610]	14
GO:0032133	chromosome passenger complex	Cellular Component	TAS[19774610]	1
GO:0051233	spindle midzone	Cellular Component	IDA[15670791]	3
GO:0005819	spindle	Cellular Component	TAS[19774610]	29
GO:0006468	protein phosphorylation	Biological Process	IDA[15670791]	53
GO:0007126	meiosis	Biological Process		11
GO:0008608	attachment of spindle microtubules to kinetochore	Biological Process	TAS[19774610]	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	Molecular Function	TAS[19774610]	2
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0000793	condensed chromosome	Cellular Component	IDA[15670791]	4
GO:0000910	cytokinesis	Biological Process	TAS[10066797]	15
GO:0004672	protein kinase activity	Molecular Function	IDA[15670791]	27
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with AURKC (count: 15)

Gene Symbol	Pathway Count	Pathway List
PLK1	9	midbody; spindle midzone; spindle; protein phosphorylation; ATP binding; nucleus; cytokinesis; protein kinase activity; protein serine/threonine kinase activity;
KIF23	7	positive regulation of cell cycle cytokinesis; spindle midzone assembly involved in mitosis; midbody; spindle; ATP binding; nucleus; cytokinesis;
NEK6	6	protein phosphorylation; ATP binding; nucleus; cytoplasm; cytokinesis; protein serine/threonine kinase activity;
SMC3	5	chromosome, centromeric region; meiosis; ATP binding; nucleus; cytoplasm;
MAPK1	5	spindle; ATP binding; nucleus; cytoplasm; protein serine/threonine kinase activity;
CSNK1E	5	protein phosphorylation; ATP binding; nucleus; protein kinase activity; protein serine/threonine kinase activity;
GSK3B	5	protein phosphorylation; ATP binding; nucleus; cytoplasm; protein serine/threonine kinase activity;
MAP3K11	5	protein phosphorylation; ATP binding; cytoplasm; protein kinase activity; protein serine/threonine kinase activity;
PAK1	5	protein phosphorylation; ATP binding; cytoplasm; protein kinase activity; protein serine/threonine kinase activity;
PRKCB	5	protein phosphorylation; ATP binding; nucleus; cytoplasm; protein serine/threonine kinase activity;
ROCK2	5	protein phosphorylation; ATP binding; nucleus; cytokinesis; protein serine/threonine kinase activity;
RPS6KA4	5	protein phosphorylation; ATP binding; nucleus; cytoplasm; protein serine/threonine kinase activity;
SIK2	5	protein phosphorylation; ATP binding; nucleus; cytoplasm; protein serine/threonine kinase activity;
STK36	5	protein phosphorylation; ATP binding; nucleus; cytoplasm; protein serine/threonine kinase activity;
SMG1	5	ATP binding; nucleus; cytoplasm; protein kinase activity; protein serine/threonine kinase activity;

Genes shared at least 2 KEGG pathways with AURKC (count: 0)

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Region: chr19:57742377..57746916 View in gBrowse