ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IHH
Symbol Alias	HHG2, BDA1
Approved Name	indian hedgehog
Previous Name	"Indian hedgehog (Drosophila) homolog", "Indian hedgehog homolog (Drosophila)"
Location	2q33-q35
Position	chr2:219919142-219925189, -1
External Links	HGNC: 5956 Entrez Gene: 3549 Ensembl: ENSG00000163501 UCSC: uc002vjo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 47)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 47)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003406	retinal pigment epithelium development	biological process	IEA	2
GO:0040008	regulation of growth	biological process	IEA	7
GO:0032967	positive regulation of collagen biosynthetic process	biological process	IEA	4
GO:0046639	negative regulation of alpha-beta T cell differentiation	biological process	ISS	1
GO:0061053	somite development	biological process	ISS	2
GO:0048596	embryonic camera-type eye morphogenesis	biological process	IEA	3
GO:0035988	chondrocyte proliferation	biological process	IEA	2
GO:0006508	proteolysis	biological process	IEA	123
GO:0072498	embryonic skeletal joint development	biological process	IEA	1
GO:0048666	neuron development	biological process	IEA	8
GO:0060323	head morphogenesis	biological process	IEA	1
GO:0001649	osteoblast differentiation	biological process	IEA	10
GO:0009880	embryonic pattern specification	biological process	IEA	4
GO:0005886	plasma membrane	cellular component	IEA	839
GO:0090136	epithelial cell-cell adhesion	biological process	IEA	1
GO:0003382	epithelial cell morphogenesis	biological process	IEA	2
GO:0005576	extracellular region	cellular component	NAS	267
GO:0033089	positive regulation of T cell differentiation in thymus	biological process	ISS	4
GO:0015485	cholesterol binding	molecular function	NAS	10
GO:0005615	extracellular space	cellular component	IEA	133
GO:0016539	intein-mediated protein splicing	biological process	IEA	1
GO:0051216	cartilage development	biological process	IEA	12
GO:0048074	negative regulation of eye pigmentation	biological process	IEA	1
GO:0001708	cell fate specification	biological process	IEA	4
GO:0048469	cell maturation	biological process	IEA	7
GO:0001701	in utero embryonic development	biological process	IEA	39
GO:0045880	positive regulation of smoothened signaling pathway	biological process	ISS	3
GO:0046638	positive regulation of alpha-beta T cell differentiation	biological process	ISS	2
GO:0031012	extracellular matrix	cellular component	IEA	29
GO:0045453	bone resorption	biological process	IEA	4
GO:0001947	heart looping	biological process	ISS	5
GO:0007267	cell-cell signaling	biological process	NAS	41
GO:0048557	embryonic digestive tract morphogenesis	biological process	IEA	7
GO:0048745	smooth muscle tissue development	biological process	IEA	3
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	141
GO:0030704	vitelline membrane formation	biological process	IEA	1
GO:0007224	smoothened signaling pathway	biological process	IEA	9
GO:0035264	multicellular organism growth	biological process	IEA	10
GO:0006029	proteoglycan metabolic process	biological process	IEA	2
GO:0001569	patterning of blood vessels	biological process	IEA	8
GO:0033088	negative regulation of immature T cell proliferation in thymus	biological process	ISS	2
GO:0008233	peptidase activity	molecular function	IEA	17
GO:0033085	negative regulation of T cell differentiation in thymus	biological process	ISS	1
GO:0060220	camera-type eye photoreceptor cell fate commitment	biological process	IEA	1
GO:0005113	patched binding	molecular function	NAS	2
GO:0031016	pancreas development	biological process	IEA	6
GO:0002053	positive regulation of mesenchymal cell proliferation	biological process	IEA	9

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8

Genes shared at least 5 GO terms with IHH (count: 9)

Gene Symbol	Pathway Count	Pathway List
FGF10	8	embryonic pattern specification; plasma membrane; extracellular region; extracellular space; extracellular matrix; embryonic digestive tract morphogenesis; positive regulation of transcription from RNA polymerase II promoter; pancreas development;
VEGFA	7	extracellular region; extracellular space; cell maturation; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; positive regulation of mesenchymal cell proliferation;
CTSG	6	proteolysis; plasma membrane; extracellular region; extracellular space; extracellular matrix; peptidase activity;
FGF9	6	osteoblast differentiation; extracellular region; extracellular space; positive regulation of smoothened signaling pathway; cell-cell signaling; positive regulation of mesenchymal cell proliferation;
FOXF1	6	in utero embryonic development; embryonic digestive tract morphogenesis; positive regulation of transcription from RNA polymerase II promoter; smoothened signaling pathway; pancreas development; positive regulation of mesenchymal cell proliferation;
IL18	5	positive regulation of collagen biosynthetic process; osteoblast differentiation; extracellular region; extracellular space; cell-cell signaling;
CTGF	5	positive regulation of collagen biosynthetic process; chondrocyte proliferation; plasma membrane; extracellular region; extracellular space;
PTCH1	5	somite development; plasma membrane; cholesterol binding; smoothened signaling pathway; patched binding;
CDON	5	plasma membrane; cell fate specification; extracellular matrix; positive regulation of transcription from RNA polymerase II promoter; smoothened signaling pathway;

Genes shared at least 2 KEGG pathways with IHH (count: 0)

View in gBrowse

Region: chr2:219919142..219925189 View in gBrowse