ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IHH
Symbol Alias	HHG2, BDA1
Approved Name	Indian hedgehog
Previous Name	Indian hedgehog (Drosophila) homolog, "Indian hedgehog homolog (Drosophila)"
Location	2q33-q35
Position	chr2:219919142-219925238, -
External Links	HGNC: 5956 Entrez Gene: 3549 Ensembl: ENSG00000163501 UCSC: uc002vjo.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 47)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 47)

ID	Name	Type	No. of Genes in ADHDgene
GO:0031012	extracellular matrix	Cellular Component	28
GO:0031016	pancreas development	Biological Process	5
GO:0016539	intein-mediated protein splicing	Biological Process	1
GO:0030704	vitelline membrane formation	Biological Process	1
GO:0009880	embryonic pattern specification	Biological Process	5
GO:0015485	cholesterol binding	Molecular Function	10
GO:0007267	cell-cell signaling	Biological Process	38
GO:0008233	peptidase activity	Molecular Function	15
GO:0040008	regulation of growth	Biological Process	5
GO:0045453	bone resorption	Biological Process	4
GO:0035264	multicellular organism growth	Biological Process	10
GO:0035988	chondrocyte proliferation	Biological Process	2
GO:0033088	negative regulation of immature T cell proliferation in thymus	Biological Process	2
GO:0033089	positive regulation of T cell differentiation in thymus	Biological Process	4
GO:0032967	positive regulation of collagen biosynthetic process	Biological Process	4
GO:0033085	negative regulation of T cell differentiation in thymus	Biological Process	1
GO:0003382	epithelial cell morphogenesis	Biological Process	2
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process	9
GO:0001947	heart looping	Biological Process	5
GO:0001708	cell fate specification	Biological Process	4
GO:0001701	in utero embryonic development	Biological Process	32
GO:0001649	osteoblast differentiation	Biological Process	9
GO:0001569	patterning of blood vessels	Biological Process	7
GO:0007224	smoothened signaling pathway	Biological Process	10
GO:0006508	proteolysis	Biological Process	102
GO:0006029	proteoglycan metabolic process	Biological Process	2
GO:0005886	plasma membrane	Cellular Component	772
GO:0005615	extracellular space	Cellular Component	126
GO:0005576	extracellular region	Cellular Component	240
GO:0005113	patched binding	Molecular Function	2
GO:0003406	retinal pigment epithelium development	Biological Process	2
GO:0048469	cell maturation	Biological Process	6
GO:0048074	negative regulation of eye pigmentation	Biological Process	1
GO:0048596	embryonic camera-type eye morphogenesis	Biological Process	3
GO:0048557	embryonic digestive tract morphogenesis	Biological Process	7
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	131
GO:0045880	positive regulation of smoothened signaling pathway	Biological Process	3
GO:0046639	negative regulation of alpha-beta T cell differentiation	Biological Process	1
GO:0046638	positive regulation of alpha-beta T cell differentiation	Biological Process	2
GO:0061053	somite development	Biological Process	2
GO:0060323	head morphogenesis	Biological Process	1
GO:0090136	epithelial cell-cell adhesion	Biological Process	1
GO:0072498	embryonic skeletal joint development	Biological Process	1
GO:0048745	smooth muscle tissue development	Biological Process	3
GO:0048666	neuron development	Biological Process	7
GO:0060220	camera-type eye photoreceptor cell fate commitment	Biological Process	1
GO:0051216	cartilage development	Biological Process	11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8	The Hedgehog (Hh) family of secreted signaling proteins play...... The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. More...

Genes shared at least 5 GO terms with IHH (count: 9)

Gene Symbol	Pathway Count	Pathway List
FGF10	8	extracellular matrix; pancreas development; embryonic pattern specification; plasma membrane; extracellular space; extracellular region; embryonic digestive tract morphogenesis; positive regulation of transcription from RNA polymerase II promoter;
VEGFA	7	positive regulation of mesenchymal cell proliferation; in utero embryonic development; patterning of blood vessels; extracellular space; extracellular region; cell maturation; positive regulation of transcription from RNA polymerase II promoter;
CTSG	6	extracellular matrix; peptidase activity; proteolysis; plasma membrane; extracellular space; extracellular region;
FOXF1	6	pancreas development; positive regulation of mesenchymal cell proliferation; in utero embryonic development; smoothened signaling pathway; embryonic digestive tract morphogenesis; positive regulation of transcription from RNA polymerase II promoter;
FGF9	6	cell-cell signaling; positive regulation of mesenchymal cell proliferation; osteoblast differentiation; extracellular space; extracellular region; positive regulation of smoothened signaling pathway;
CDON	5	extracellular matrix; cell fate specification; smoothened signaling pathway; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
PTCH1	5	cholesterol binding; smoothened signaling pathway; plasma membrane; patched binding; somite development;
IL18	5	cell-cell signaling; positive regulation of collagen biosynthetic process; osteoblast differentiation; extracellular space; extracellular region;
CTGF	5	chondrocyte proliferation; positive regulation of collagen biosynthetic process; plasma membrane; extracellular space; extracellular region;

Genes shared at least 2 KEGG pathways with IHH (count: 0)

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Region: chr2:219919142..219925238 View in gBrowse