ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PVRL1
Previous Symbol	HVEC, ED4
Symbol Alias	PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7
Approved Name	poliovirus receptor-related 1 (herpesvirus entry mediator C)
Name Alias	nectin
Location	11q23-q24
Position	chr11:119494120-119599794, -
External Links	HGNC: 9706 Entrez Gene: 5818 Ensembl: ENSG00000110400 UCSC: uc001pwv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007156	homophilic cell adhesion	Biological Process		27
GO:0007155	cell adhesion	Biological Process	NAS[12764381]	86
GO:0015026	coreceptor activity	Molecular Function	TAS[9616127]	4
GO:0007157	heterophilic cell-cell adhesion	Biological Process		11
GO:0016021	integral to membrane	Cellular Component	NAS[10932188]	845
GO:0016020	membrane	Cellular Component	TAS[9616127]	139
GO:0034329	cell junction assembly	Biological Process		13
GO:0016337	cell-cell adhesion	Biological Process	NAS[12885915]	13
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0034332	adherens junction organization	Biological Process		9
GO:0046718	viral entry into host cell	Biological Process	NAS[12885915]	2
GO:0045216	cell-cell junction organization	Biological Process		10
GO:0060041	retina development in camera-type eye	Biological Process		8
GO:0050839	cell adhesion molecule binding	Molecular Function	IPI[12438620]	9
GO:0070166	enamel mineralization	Biological Process		2
GO:0002089	lens morphogenesis in camera-type eye	Biological Process		3
GO:0005576	extracellular region	Cellular Component		240
GO:0005886	plasma membrane	Cellular Component		772
GO:0002934	desmosome organization	Biological Process		1
GO:0005515	protein binding	Molecular Function		910
GO:0006826	iron ion transport	Biological Process		4
GO:0006955	immune response	Biological Process	NAS[10932188]	45
GO:0005912	adherens junction	Cellular Component	NAS[12885915]	9
GO:0005913	cell-cell adherens junction	Cellular Component	IDA[10225955]	9

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...
hsa04520	Adherens junction	14	Cell-cell adherens junctions (AJs), the most common type of ...... Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion. More...

Genes shared at least 5 GO terms with PVRL1 (count: 18)

Gene Symbol	Pathway Count	Pathway List
CADM1	10	homophilic cell adhesion; heterophilic cell-cell adhesion; integral to membrane; cell junction assembly; protein homodimerization activity; adherens junction organization; cell-cell junction organization; cell adhesion molecule binding; plasma membrane; protein binding;
CDH2	9	homophilic cell adhesion; cell adhesion; heterophilic cell-cell adhesion; integral to membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; plasma membrane; cell-cell adherens junction;
CTNND1	8	cell adhesion; cell junction assembly; cell-cell adhesion; adherens junction organization; cell-cell junction organization; plasma membrane; protein binding; cell-cell adherens junction;
CDH12	7	homophilic cell adhesion; integral to membrane; cell junction assembly; cell-cell adhesion; adherens junction organization; cell-cell junction organization; plasma membrane;
CDH15	7	homophilic cell adhesion; cell adhesion; integral to membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; plasma membrane;
CDH4	7	homophilic cell adhesion; cell adhesion; heterophilic cell-cell adhesion; cell junction assembly; adherens junction organization; cell-cell junction organization; plasma membrane;
CDH6	7	homophilic cell adhesion; cell adhesion; integral to membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; plasma membrane;
ACHE	7	cell adhesion; membrane; protein homodimerization activity; retina development in camera-type eye; extracellular region; plasma membrane; protein binding;
DSC3	6	homophilic cell adhesion; cell adhesion; integral to membrane; membrane; extracellular region; plasma membrane;
NRXN1	6	cell adhesion; heterophilic cell-cell adhesion; integral to membrane; cell adhesion molecule binding; plasma membrane; protein binding;
CDH13	5	homophilic cell adhesion; cell junction assembly; adherens junction organization; cell-cell junction organization; plasma membrane;
CDH23	5	homophilic cell adhesion; integral to membrane; membrane; plasma membrane; protein binding;
CDHR5	5	homophilic cell adhesion; cell adhesion; integral to membrane; membrane; plasma membrane;
DSC2	5	homophilic cell adhesion; cell adhesion; integral to membrane; plasma membrane; cell-cell adherens junction;
APC	5	cell adhesion; retina development in camera-type eye; plasma membrane; protein binding; cell-cell adherens junction;
ENPP1	5	integral to membrane; protein homodimerization activity; plasma membrane; protein binding; immune response;
GHR	5	integral to membrane; protein homodimerization activity; extracellular region; plasma membrane; protein binding;
IL7R	5	integral to membrane; extracellular region; plasma membrane; protein binding; immune response;

Genes shared at least 2 KEGG pathways with PVRL1 (count: 0)

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Region: chr11:119494120..119599794 View in gBrowse