ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PVRL1
Previous Symbol	HVEC, ED4
Symbol Alias	PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7
Approved Name	poliovirus receptor-related 1 (herpesvirus entry mediator C)
Name Alias	"nectin"
Location	11q23-q24
Position	chr11:119494120-119599794, -1
External Links	HGNC: 9706 Entrez Gene: 5818 Ensembl: ENSG00000110400 UCSC: uc001pwv.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016021	integral to membrane	cellular component	NAS[10932188]	932
GO:0007156	homophilic cell adhesion	biological process	ISS	31
GO:0005515	protein binding	molecular function	IPI	1015
GO:0016337	cell-cell adhesion	biological process	NAS[12885915]	15
GO:0006955	immune response	biological process	NAS[10932188]	51
GO:0005913	cell-cell adherens junction	cellular component	IDA[10225955]	9
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0002089	lens morphogenesis in camera-type eye	biological process	IEA	3
GO:0045216	cell-cell junction organization	biological process	TAS	15
GO:0016020	membrane	cellular component	TAS[9616127]	155
GO:0006826	iron ion transport	biological process	IEA	4
GO:0002934	desmosome organization	biological process	IEA	1
GO:0042803	protein homodimerization activity	molecular function	ISS	128
GO:0034332	adherens junction organization	biological process	TAS	13
GO:0005576	extracellular region	cellular component	IEA	267
GO:0070166	enamel mineralization	biological process	IEA	2
GO:0007157	heterophilic cell-cell adhesion	biological process	ISS	11
GO:0015026	coreceptor activity	molecular function	TAS[9616127]	4
GO:0005912	adherens junction	cellular component	NAS[12885915]	9
GO:0050839	cell adhesion molecule binding	molecular function	IPI[12438620]	9
GO:0034329	cell junction assembly	biological process	TAS	18
GO:0007155	cell adhesion	biological process	NAS[12764381]	99
GO:0060041	retina development in camera-type eye	biological process	IEA	9
GO:0046718	viral entry into host cell	biological process	NAS[12885915]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04520	Adherens junction	15
hsa04514	Cell adhesion molecules (CAMs)	27

Genes shared at least 5 GO terms with PVRL1 (count: 22)

Gene Symbol	Pathway Count	Pathway List
CADM1	10	integral to membrane; homophilic cell adhesion; protein binding; plasma membrane; cell-cell junction organization; protein homodimerization activity; adherens junction organization; heterophilic cell-cell adhesion; cell adhesion molecule binding; cell junction assembly;
CDH2	9	integral to membrane; homophilic cell adhesion; cell-cell adherens junction; plasma membrane; cell-cell junction organization; adherens junction organization; heterophilic cell-cell adhesion; cell junction assembly; cell adhesion;
CTNND1	8	protein binding; cell-cell adhesion; cell-cell adherens junction; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly; cell adhesion;
CDH6	7	integral to membrane; homophilic cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly; cell adhesion;
CDH10	7	integral to membrane; homophilic cell adhesion; cell-cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly;
CDH9	7	integral to membrane; homophilic cell adhesion; cell-cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly;
CDH12	7	integral to membrane; homophilic cell adhesion; cell-cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly;
CDH15	7	integral to membrane; homophilic cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly; cell adhesion;
CDH4	7	homophilic cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; heterophilic cell-cell adhesion; cell junction assembly; cell adhesion;
ACHE	7	protein binding; plasma membrane; membrane; protein homodimerization activity; extracellular region; cell adhesion; retina development in camera-type eye;
CADM2	6	integral to membrane; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly; cell adhesion;
NRXN1	6	integral to membrane; protein binding; plasma membrane; heterophilic cell-cell adhesion; cell adhesion molecule binding; cell adhesion;
CDH18	6	integral to membrane; homophilic cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly;
DSC3	6	integral to membrane; homophilic cell adhesion; plasma membrane; membrane; extracellular region; cell adhesion;
ENPP1	5	integral to membrane; protein binding; immune response; plasma membrane; protein homodimerization activity;
CDH23	5	integral to membrane; homophilic cell adhesion; protein binding; plasma membrane; membrane;
GHR	5	integral to membrane; protein binding; plasma membrane; protein homodimerization activity; extracellular region;
IL7R	5	integral to membrane; protein binding; immune response; plasma membrane; extracellular region;
CDHR5	5	integral to membrane; homophilic cell adhesion; plasma membrane; membrane; cell adhesion;
DSC2	5	integral to membrane; homophilic cell adhesion; cell-cell adherens junction; plasma membrane; cell adhesion;
CDH13	5	homophilic cell adhesion; plasma membrane; cell-cell junction organization; adherens junction organization; cell junction assembly;
APC	5	protein binding; cell-cell adherens junction; plasma membrane; cell adhesion; retina development in camera-type eye;

Genes shared at least 2 KEGG pathways with PVRL1 (count: 0)

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Region: chr11:119494120..119599794 View in gBrowse