ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CDH23
Previous Symbol	DFNB12, USH1D
Symbol Alias	CDHR23
Approved Name	cadherin-related 23
Previous Name	cadherin related 23, "cadherin-like 23"
Name Alias	cadherin-related family member 23
Location	10q22.1
Position	chr10:73156691-73575704, +
External Links	HGNC: 13733 Entrez Gene: 64072 Ensembl: ENSG00000107736 UCSC: uc001jrx.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	No significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11594082	Chr10:73299253(Fwd)	feature_truncation; intron_variant; nc_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs16929022	Chr10:73296629(Fwd)	intron_variant; nc_transcript_variant
rs17634834	Chr10:73286290(Fwd)	intron_variant; nc_transcript_variant
rs11594877	Chr10:73295727(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045494	photoreceptor cell maintenance	Biological Process	IMP[16679490]	3
GO:0050896	response to stimulus	Biological Process		8
GO:0016339	calcium-dependent cell-cell adhesion	Biological Process	NAS[11138009]	8
GO:0032420	stereocilium	Cellular Component	ISS[12485990]	6
GO:0051480	cytosolic calcium ion homeostasis	Biological Process	IMP[17234811]	6
GO:0050953	sensory perception of light stimulus	Biological Process	IMP[16679490]	3
GO:0050957	equilibrioception	Biological Process	IMP[16679490]	2
GO:0006816	calcium ion transport	Biological Process	IMP[17234811]	32
GO:0005886	plasma membrane	Cellular Component		772
GO:0005515	protein binding	Molecular Function	IPI[12485990]	910
GO:0005509	calcium ion binding	Molecular Function		124
GO:0016021	integral to membrane	Cellular Component		845
GO:0016020	membrane	Cellular Component	NAS[11138009]	139
GO:0007605	sensory perception of sound	Biological Process	IMP[16679490]	31
GO:0007156	homophilic cell adhesion	Biological Process		27

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CDH23 (count: 10)

Gene Symbol	Pathway Count	Pathway List
CDHR5	6	calcium-dependent cell-cell adhesion; plasma membrane; calcium ion binding; integral to membrane; membrane; homophilic cell adhesion;
DCHS1	6	calcium-dependent cell-cell adhesion; plasma membrane; calcium ion binding; integral to membrane; membrane; homophilic cell adhesion;
RYR2	6	cytosolic calcium ion homeostasis; calcium ion transport; plasma membrane; protein binding; calcium ion binding; membrane;
CDH2	5	calcium-dependent cell-cell adhesion; plasma membrane; calcium ion binding; integral to membrane; homophilic cell adhesion;
DSG1	5	calcium-dependent cell-cell adhesion; plasma membrane; calcium ion binding; integral to membrane; homophilic cell adhesion;
MYO7A	5	stereocilium; sensory perception of light stimulus; equilibrioception; protein binding; sensory perception of sound;
PLN	5	cytosolic calcium ion homeostasis; calcium ion transport; protein binding; integral to membrane; membrane;
DSC1	5	plasma membrane; calcium ion binding; integral to membrane; membrane; homophilic cell adhesion;
DSC3	5	plasma membrane; calcium ion binding; integral to membrane; membrane; homophilic cell adhesion;
PVRL1	5	plasma membrane; protein binding; integral to membrane; membrane; homophilic cell adhesion;

Genes shared at least 2 KEGG pathways with CDH23 (count: 0)

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Region: chr10:73156691..73575704 View in gBrowse