ADHDgene Database

Gene Report

Basic Info

Approved Symbol	FLNC
Previous Symbol	FLN2
Symbol Alias	ABP-280, ABPL
Approved Name	filamin C, gamma
Previous Name	"filamin C, gamma (actin binding protein 280)"
Name Alias	"actin binding protein 280"
Location	7q32-q35
Position	chr7:128470431-128499328, 1
External Links	HGNC: 3756 Entrez Gene: 2318 Ensembl: ENSG00000128591 UCSC: uc003vnz.4
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (b)	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2291560	chr7:128477472(Fwd)	synonymous_variant; upstream_gene_variant	1(0/1/0)
rs2291567	chr7:128483227(Fwd)	downstream_gene_variant; intron_variant	1(0/0/1)
rs3734973	chr7:128484816(Fwd)	downstream_gene_variant; synonymous_variant	1(0/0/1)
rs13227216	chr7:128490553(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs3734972	chr7:128470838(Fwd)	synonymous_variant
rs1994765	chr7:128472981(Fwd)	intron_variant
rs2291561	chr7:128477547(Fwd)	synonymous_variant; upstream_gene_variant
rs1472147	chr7:128503543(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1472146	chr7:128503942(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005856	cytoskeleton	cellular component	IEA	56
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0042383	sarcolemma	cellular component	IDA	12
GO:0005515	protein binding	molecular function	IPI[17474147]	1015
GO:0005829	cytosol	cellular component	TAS	485
GO:0048747	muscle fiber development	biological process	IEA	1
GO:0034329	cell junction assembly	biological process	TAS	18
GO:0008092	cytoskeletal protein binding	molecular function	IPI[17987659]	11
GO:0016528	sarcoplasm	cellular component	IEA	1
GO:0030506	ankyrin binding	molecular function	IPI	3
GO:0005886	plasma membrane	cellular component	IDA	839
GO:0003779	actin binding	molecular function	IEA	48
GO:0043034	costamere	cellular component	TAS	4
GO:0030018	Z disc	cellular component	IEA	17

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	68
hsa04510	Focal adhesion	40

Genes shared at least 5 GO terms with FLNC (count: 11)

Gene Symbol	Pathway Count	Pathway List
ILK	6	cytoplasm; protein binding; cytosol; cell junction assembly; plasma membrane; costamere;
FHOD3	5	cytoskeleton; cytoplasm; protein binding; actin binding; Z disc;
NOS1	5	cytoskeleton; cytoplasm; sarcolemma; protein binding; cytosol;
RDX	5	cytoskeleton; cytoplasm; protein binding; plasma membrane; actin binding;
NF2	5	cytoskeleton; cytoplasm; protein binding; cytoskeletal protein binding; plasma membrane;
PAK1	5	cytoplasm; protein binding; cytosol; plasma membrane; Z disc;
CRYAB	5	cytoplasm; protein binding; cytosol; plasma membrane; Z disc;
INPPL1	5	cytoplasm; protein binding; cytosol; plasma membrane; actin binding;
CTNND1	5	cytoplasm; protein binding; cytosol; cell junction assembly; plasma membrane;
DES	5	sarcolemma; protein binding; cytosol; cytoskeletal protein binding; Z disc;
ANK3	5	sarcolemma; protein binding; cytoskeletal protein binding; plasma membrane; costamere;

Genes shared at least 2 KEGG pathways with FLNC (count: 5)

Gene Symbol	Pathway Count	Pathway List
MAPK1	2	MAPK signaling pathway; Focal adhesion;
MAPK3	2	MAPK signaling pathway; Focal adhesion;
CRKL	2	MAPK signaling pathway; Focal adhesion;
PAK1	2	MAPK signaling pathway; Focal adhesion;
MAPK9	2	MAPK signaling pathway; Focal adhesion;

View in gBrowse

Region: chr7:128470431..128499328 View in gBrowse