ADHDgene Database

SNP Report

Basic Info

Name	rs2394534 dbSNP Ensembl
Location	chr10:71029302(Fwd)
Variant Alleles	T/G
Ancestral Allele	T
Functional Annotation	downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000354624) upstream_gene_variant(ENST00000360289; ENST00000413220; ENST00000448642; ENST00000450646; ENST00000464803; ENST00000476368; ENST00000479594; ENST00000480047; ENST00000483077; LRG_365t1)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Neale BM, 2010 (b)	T:G		GLM P-value=1.04E-05, meta-analysis P-value=0.02563 GLM P-value=1.04E-05, meta-analysis P-value=0.02563	One of the top 100 SNPs from imputed IMAGE II dataset One of the top 100 SNPs from imputed IMAGE II dataset	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
HKDC1	hexokinase domain containing 1	10q22.1	1(0/1/0)
HK1	hexokinase 1	10q22	1(0/1/0)

SNPs in LD with rs2394534 (count: 6) View in gBrowse (chr10:71010375..71052888 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs10823333	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[CHD]; 0.897[JPT]
rs12218331	intron_variant; nc_transcript_variant	1.0[YRI]
rs10762271	downstream_gene_variant; intron_variant	0.823[CHB]; 1.0[CHD]; 0.823[JPT]; 0.887[GIH]
rs5030948	downstream_gene_variant; synonymous_variant	0.823[CHB]; 1.0[CHD]; 0.823[JPT]; 0.824[GIH]
rs10823325	intron_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs1027793	intron_variant; upstream_gene_variant	0.823[CHB]; 1.0[CHD]; 0.823[JPT]; 0.941[GIH]