ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ALDOB
Approved Name	aldolase B, fructose-bisphosphate
Location	9q21.3-q22.2
Position	chr9:104182842-104198105, -
External Links	HGNC: 417 Entrez Gene: 229 Ensembl: ENSG00000136872 UCSC: uc004bbk.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008092	cytoskeletal protein binding	Molecular Function	IDA[9244396]	11
GO:0006116	NADH oxidation	Biological Process	IDA[17576770]	1
GO:0032781	positive regulation of ATPase activity	Biological Process	IGI[17576770]	3
GO:0030388	fructose 1,6-bisphosphate metabolic process	Biological Process	IDA[10625657]	2
GO:0042802	identical protein binding	Molecular Function	IPI[10625657]	70
GO:0034451	centriolar satellite	Cellular Component	IDA[18000879]	4
GO:0051117	ATPase binding	Molecular Function	IDA[17576770]	7
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0005829	cytosol	Cellular Component		447
GO:0005815	microtubule organizing center	Cellular Component	IDA[18000879]	19
GO:0006000	fructose metabolic process	Biological Process	IMP[3383242]	4
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0006006	glucose metabolic process	Biological Process		19
GO:0006001	fructose catabolic process	Biological Process		1
GO:0006096	glycolysis	Biological Process	IDA[10625657]	4
GO:0006094	gluconeogenesis	Biological Process		6
GO:0004332	fructose-bisphosphate aldolase activity	Molecular Function	IDA[17576770]	2
GO:0005515	protein binding	Molecular Function	IPI[18000879]	910
GO:0070061	fructose binding	Molecular Function	IMP[10625657]	2
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	Biological Process	IGI[17576770]	1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00030	Pentose phosphate pathway	4	The pentose phosphate pathway is a process of glucose turnov...... The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008]. More...
hsa00051	Fructose and mannose metabolism	11
hsa00010	Glycolysis / Gluconeogenesis	11	Glycolysis is the process of converting glucose into pyruvat...... Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. More...

Genes shared at least 5 GO terms with ALDOB (count: 4)

Gene Symbol	Pathway Count	Pathway List
ALDOA	12	cytoskeletal protein binding; fructose 1,6-bisphosphate metabolic process; identical protein binding; small molecule metabolic process; cytosol; fructose metabolic process; carbohydrate metabolic process; glucose metabolic process; glycolysis; gluconeogenesis; fructose-bisphosphate aldolase activity; fructose binding;
FBP1	7	small molecule metabolic process; cytosol; fructose metabolic process; carbohydrate metabolic process; glucose metabolic process; gluconeogenesis; protein binding;
FBP2	6	small molecule metabolic process; cytosol; fructose metabolic process; carbohydrate metabolic process; glucose metabolic process; gluconeogenesis;
HK1	5	small molecule metabolic process; cytosol; carbohydrate metabolic process; glycolysis; protein binding;

Genes shared at least 2 KEGG pathways with ALDOB (count: 14)

Gene Symbol	Pathway Count	Pathway List
ALDOA	4	Metabolic pathways; Pentose phosphate pathway; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
FBP1	4	Metabolic pathways; Pentose phosphate pathway; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
FBP2	4	Metabolic pathways; Pentose phosphate pathway; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
HK1	3	Metabolic pathways; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
HKDC1	3	Metabolic pathways; Fructose and mannose metabolism; Glycolysis / Gluconeogenesis;
ALDH3A1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3A2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3B1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3B2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
DLAT	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
GMDS	2	Metabolic pathways; Fructose and mannose metabolism;
GMPPA	2	Metabolic pathways; Fructose and mannose metabolism;
SORD	2	Metabolic pathways; Fructose and mannose metabolism;
TSTA3	2	Metabolic pathways; Fructose and mannose metabolism;

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Region: chr9:104182842..104198105 View in gBrowse