Gene Report
Basic Info
Approved Symbol |
POLR3E
|
Symbol Alias |
RPC5, SIN, FLJ10509 |
Approved Name |
polymerase (RNA) III (DNA directed) polypeptide E (80kD) |
Location |
16p12 |
Position |
chr16:22308730-22346424, + |
External Links |
HGNC: 30347
Entrez Gene: 55718
Ensembl: ENSG00000058600
UCSC: uc002dkk.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV; Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 10)
Gene related KEGG pathways (count: 4)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa03020 |
RNA polymerase |
3 |
|
hsa00230 |
Purine metabolism |
22 |
|
hsa00240 |
Pyrimidine metabolism |
13 |
|
hsa04623 |
Cytosolic DNA-sensing pathway |
9 |
Specific families of pattern recognition receptors are respo......
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
More...
|
Genes shared at least 5 GO terms with POLR3E (count: 1)
Genes shared at least 2 KEGG pathways with POLR3E (count: 10)
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