ADHDgene Database

Gene Report

Basic Info

Approved Symbol	APRT
Approved Name	adenine phosphoribosyltransferase
Location	16q24
Position	chr16:88875877-88878342, -
External Links	HGNC: 626 Entrez Gene: 353 Ensembl: ENSG00000198931 UCSC: uc002flv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002055	adenine binding	Molecular Function		1
GO:0003999	adenine phosphoribosyltransferase activity	Molecular Function		1
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component	TAS[16130169]	690
GO:0005829	cytosol	Cellular Component		447
GO:0006144	purine nucleobase metabolic process	Biological Process		4
GO:0006166	purine ribonucleoside salvage	Biological Process		1
GO:0006168	adenine salvage	Biological Process		1
GO:0007595	lactation	Biological Process		7
GO:0007625	grooming behavior	Biological Process		3
GO:0016208	AMP binding	Molecular Function	IDA[15196008]	3
GO:0032869	cellular response to insulin stimulus	Biological Process		7
GO:0043101	purine-containing compound salvage	Biological Process		3
GO:0044209	AMP salvage	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0055086	nucleobase-containing small molecule metabolic process	Biological Process		9

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with APRT (count: 4)

Gene Symbol	Pathway Count	Pathway List
LPIN1	5	nucleus; cytoplasm; cytosol; cellular response to insulin stimulus; small molecule metabolic process;
PPP1CA	5	nucleus; nucleolus; cytoplasm; cytosol; small molecule metabolic process;
ADAL	5	cytosol; purine nucleobase metabolic process; purine-containing compound salvage; small molecule metabolic process; nucleobase-containing small molecule metabolic process;
GMPR2	5	cytosol; purine nucleobase metabolic process; purine-containing compound salvage; small molecule metabolic process; nucleobase-containing small molecule metabolic process;

Genes shared at least 2 KEGG pathways with APRT (count: 13)

Gene Symbol	Pathway Count	Pathway List
ATIC	2	Purine metabolism; Metabolic pathways;
ENPP1	2	Purine metabolism; Metabolic pathways;
ENPP3	2	Purine metabolism; Metabolic pathways;
ITPA	2	Purine metabolism; Metabolic pathways;
NT5M	2	Purine metabolism; Metabolic pathways;
POLA2	2	Purine metabolism; Metabolic pathways;
POLD3	2	Purine metabolism; Metabolic pathways;
POLD4	2	Purine metabolism; Metabolic pathways;
POLE	2	Purine metabolism; Metabolic pathways;
POLE3	2	Purine metabolism; Metabolic pathways;
POLR1A	2	Purine metabolism; Metabolic pathways;
POLR2G	2	Purine metabolism; Metabolic pathways;
RRM2	2	Purine metabolism; Metabolic pathways;

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Region: chr16:88875877..88878342 View in gBrowse