ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DUSP1
Previous Symbol	PTPN10
Symbol Alias	HVH1, CL100, MKP-1
Approved Name	dual specificity phosphatase 1
Location	5q35.1
Position	chr5:172195093-172198198, -1
External Links	HGNC: 3064 Entrez Gene: 1843 Ensembl: ENSG00000120129 UCSC: uc003mbv.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Mick E, 2010	No significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7702178	chr5:172196997(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs322353	chr5:172192868(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs13170779	chr5:172201901(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032870	cellular response to hormone stimulus	biological process	IEA	7
GO:0009416	response to light stimulus	biological process	IEA	7
GO:0043065	positive regulation of apoptotic process	biological process	IEA	38
GO:0000188	inactivation of MAPK activity	biological process	IBA	3
GO:0032526	response to retinoic acid	biological process	IEA	8
GO:0051591	response to cAMP	biological process	IEA	12
GO:0035556	intracellular signal transduction	biological process	IEA	52
GO:0005654	nucleoplasm	cellular component	IBA	210
GO:0042542	response to hydrogen peroxide	biological process	IEA	7
GO:0051384	response to glucocorticoid stimulus	biological process	IEA	17
GO:0001706	endoderm formation	biological process	IBA	3
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	molecular function	TAS[1406996]	2
GO:0006470	protein dephosphorylation	biological process	IBA	19
GO:0006979	response to oxidative stress	biological process	TAS[1406996]	17
GO:0007049	cell cycle	biological process	IEA	36
GO:0051592	response to calcium ion	biological process	IEA	10
GO:0042981	regulation of apoptotic process	biological process	IBA	34
GO:0008330	protein tyrosine/threonine phosphatase activity	molecular function	IEA	2
GO:0005515	protein binding	molecular function	IPI[16286470]	1015
GO:0033574	response to testosterone stimulus	biological process	IEA	2
GO:0032355	response to estradiol stimulus	biological process	IEA	19
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	molecular function	IBA	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	68

Genes shared at least 5 GO terms with DUSP1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
DUSP2	8	inactivation of MAPK activity; nucleoplasm; endoderm formation; protein dephosphorylation; regulation of apoptotic process; protein tyrosine/threonine phosphatase activity; protein binding; MAP kinase tyrosine/serine/threonine phosphatase activity;
BAD	7	positive regulation of apoptotic process; response to hydrogen peroxide; response to glucocorticoid stimulus; response to calcium ion; protein binding; response to testosterone stimulus; response to estradiol stimulus;
IGFBP2	5	cellular response to hormone stimulus; response to retinoic acid; response to glucocorticoid stimulus; protein binding; response to estradiol stimulus;

Genes shared at least 2 KEGG pathways with DUSP1 (count: 0)

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Region: chr5:172195093..172198198 View in gBrowse