ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DUSP2
Symbol Alias	PAC-1
Approved Name	dual specificity phosphatase 2
Location	2q11
Position	chr2:96808905-96811179, -
External Links	HGNC: 3068 Entrez Gene: 1844 Ensembl: ENSG00000158050 UCSC: uc002svk.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 3)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function		910
GO:0004725	protein tyrosine phosphatase activity	Molecular Function		19
GO:0001706	endoderm formation	Biological Process		3
GO:0000188	inactivation of MAPK activity	Biological Process		3
GO:0008330	protein tyrosine/threonine phosphatase activity	Molecular Function	TAS[8107850]	2
GO:0006470	protein dephosphorylation	Biological Process		18
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	TAS[8107850]	770
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Molecular Function		3
GO:0035335	peptidyl-tyrosine dephosphorylation	Biological Process	TAS[7681221]	11
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0051019	mitogen-activated protein kinase binding	Molecular Function		4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with DUSP2 (count: 3)

Gene Symbol	Pathway Count	Pathway List
DUSP1	8	protein binding; endoderm formation; inactivation of MAPK activity; protein tyrosine/threonine phosphatase activity; protein dephosphorylation; nucleoplasm; MAP kinase tyrosine/serine/threonine phosphatase activity; regulation of apoptotic process;
PTPN14	5	protein binding; protein tyrosine phosphatase activity; protein dephosphorylation; nucleus; peptidyl-tyrosine dephosphorylation;
CDC14B	5	protein tyrosine phosphatase activity; protein dephosphorylation; nucleoplasm; nucleus; peptidyl-tyrosine dephosphorylation;

Genes shared at least 2 KEGG pathways with DUSP2 (count: 0)

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Region: chr2:96808905..96811179 View in gBrowse