ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SRSF8
Previous Symbol	SFRS2B
Symbol Alias	SRP46
Approved Name	serine/arginine-rich splicing factor 8
Previous Name	splicing factor, arginine/serine-rich 2B
Name Alias	SR splicing factor 8
Location	11q22
Position	chr11:94800056-94804388, +
External Links	HGNC: 16988 Entrez Gene: 10929 Ensembl: ENSG00000180771 UCSC: uc001pff.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 5)

ID	Name	Type	No. of Genes in ADHDgene
GO:0003723	RNA binding	Molecular Function	104
GO:0000166	nucleotide binding	Molecular Function	73
GO:0008380	RNA splicing	Biological Process	65
GO:0006397	mRNA processing	Biological Process	50
GO:0005634	nucleus	Cellular Component	770

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SRSF8 (count: 9)

Gene Symbol	Pathway Count	Pathway List
CPSF7	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
HNRNPA1	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
HNRNPA2B1	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
RBFOX1	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
RBM4	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
SCAF8	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
SNRNP35	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
TARDBP	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;
U2AF1	5	RNA binding; nucleotide binding; RNA splicing; mRNA processing; nucleus;

Genes shared at least 2 KEGG pathways with SRSF8 (count: 0)

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Region: chr11:94800056..94804388 View in gBrowse