ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NFIL3
Previous Symbol	IL3BP1
Symbol Alias	E4BP4, NFIL3A, NF-IL3A
Approved Name	nuclear factor, interleukin 3 regulated
Location	9q22
Position	chr9:94171327-94186144, -
External Links	HGNC: 7787 Entrez Gene: 4783 Ensembl: ENSG00000165030 UCSC: uc004arh.2
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by significant region

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Mick E, 2010	Gene-based set test P-value=0.041. Significant gene-based set tests of association with selected candidates, but contains no significant or Trend associated SNPs.	Significant
Brookes K, 2006	UNPHASED TDT P-value=0.0959, global P-value=0.685, WHAP TDT P_sum P-value=0.723, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Molecular Function		3
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	Molecular Function		6
GO:0003677	DNA binding	Molecular Function	TAS[1620116]	220
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	Molecular Function		7
GO:0003714	transcription corepressor activity	Molecular Function	TAS[1620116]	29
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[7565758]	132
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[7565758]	62
GO:0005634	nucleus	Cellular Component		770
GO:0007623	circadian rhythm	Biological Process		15
GO:0006955	immune response	Biological Process	TAS[7565758]	45

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NFIL3 (count: 9)

Gene Symbol	Pathway Count	Pathway List
TFAP2A	6	positive regulation of gene expression; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; transcription from RNA polymerase II promoter; nucleus;
DRAP1	5	negative regulation of transcription from RNA polymerase II promoter; DNA binding; transcription corepressor activity; sequence-specific DNA binding transcription factor activity; nucleus;
GATA6	5	negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
HES1	5	negative regulation of transcription from RNA polymerase II promoter; DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; sequence-specific DNA binding transcription factor activity; nucleus;
IRF7	5	negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter sequence-specific DNA binding; DNA binding; transcription from RNA polymerase II promoter; nucleus;
MEIS2	5	negative regulation of transcription from RNA polymerase II promoter; transcription corepressor activity; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
NCOR1	5	negative regulation of transcription from RNA polymerase II promoter; transcription corepressor activity; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
ZNF202	5	negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus;
ETS1	5	DNA binding; sequence-specific DNA binding transcription factor activity; transcription from RNA polymerase II promoter; nucleus; immune response;

Genes shared at least 2 KEGG pathways with NFIL3 (count: 0)

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Region: chr9:94171327..94186144 View in gBrowse