ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PKNOX2
Approved Name	PBX/knotted 1 homeobox 2
Location	11q24.2
Position	chr11:125034559-125303285, +
External Links	HGNC: 16714 Entrez Gene: 63876 Ensembl: ENSG00000165495 UCSC: uc001qbu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003677	DNA binding	Molecular Function	IDA[12412021]	220
GO:0003785	actin monomer binding	Molecular Function		2
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process		42
GO:0015629	actin cytoskeleton	Cellular Component		26
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0051015	actin filament binding	Molecular Function		14

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PKNOX2 (count: 10)

Gene Symbol	Pathway Count	Pathway List
GSC2	5	DNA binding; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HES1	5	DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; sequence-specific DNA binding;
HOXB1	5	DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; sequence-specific DNA binding;
IKZF1	5	DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; sequence-specific DNA binding;
RELA	5	DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; sequence-specific DNA binding;
SREBF1	5	DNA binding; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TBX1	5	DNA binding; sequence-specific DNA binding transcription factor activity; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
ZNF263	5	DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; microtubule cytoskeleton;
ZNF367	5	DNA binding; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; regulation of transcription from RNA polymerase II promoter;
POU2F3	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with PKNOX2 (count: 0)

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Region: chr11:125034559..125303285 View in gBrowse