ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CBX3
Symbol Alias	HP1Hs-gamma
Approved Name	chromobox homolog 3
Previous Name	chromobox homolog 3 (Drosophila HP1 gamma)
Name Alias	HP1 gamma homolog (Drosophila)
Location	7p15.2
Position	chr7:26240782-26252976, +
External Links	HGNC: 1553 Entrez Gene: 11335 Ensembl: ENSG00000122565 UCSC: uc003sxt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_6	chr7:23010000-26070000 (NCBI Build 35 (hg17))	3060000	7p15.2-7p15.3	Duplication	Paternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019904	protein domain specific binding	Molecular Function	IPI[9636147]	40
GO:0031618	nuclear centromeric heterochromatin	Cellular Component		2
GO:0042802	identical protein binding	Molecular Function		70
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[9636147]; IMP[9636147]	64
GO:0019899	enzyme binding	Molecular Function	IPI[19486527]	47
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006338	chromatin remodeling	Biological Process	NAS[8663349]	10
GO:0005819	spindle	Cellular Component	IDA[11101528]	29
GO:0005720	nuclear heterochromatin	Cellular Component	IDA[11124534]	2
GO:0005719	nuclear euchromatin	Cellular Component	IDA[11124534]	1
GO:0005637	nuclear inner membrane	Cellular Component	NAS[8663349]	2
GO:0005635	nuclear envelope	Cellular Component		19
GO:0005634	nucleus	Cellular Component	IDA[17540172]	770
GO:0005515	protein binding	Molecular Function	IPI[9636146]	910
GO:0000785	chromatin	Cellular Component	IDA[11101528]	13
GO:0000779	condensed chromosome, centromeric region	Cellular Component		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CBX3 (count: 10)

Gene Symbol	Pathway Count	Pathway List
MEN1	6	negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin remodeling; nucleus; protein binding; chromatin;
ATXN1	5	identical protein binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; protein binding;
BNIP3	5	identical protein binding; chromatin remodeling; nuclear envelope; nucleus; protein binding;
EED	5	identical protein binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; protein binding;
ZBTB16	5	identical protein binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; protein binding;
DAXX	5	negative regulation of transcription, DNA-dependent; enzyme binding; transcription, DNA-dependent; nucleus; protein binding;
HINFP	5	negative regulation of transcription, DNA-dependent; enzyme binding; transcription, DNA-dependent; nucleus; protein binding;
HMGA1	5	negative regulation of transcription, DNA-dependent; enzyme binding; transcription, DNA-dependent; nucleus; protein binding;
KAT5	5	negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; protein binding; chromatin;
KDM1A	5	negative regulation of transcription, DNA-dependent; enzyme binding; transcription, DNA-dependent; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with CBX3 (count: 0)

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Region: chr7:26240782..26252976 View in gBrowse