ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PER1
Previous Symbol	PER
Symbol Alias	RIGUI
Approved Name	period homolog 1 (Drosophila)
Previous Name	period (Drosophila) homolog 1
Location	17p13.1
Position	chr17:8043788-8059678, -
External Links	HGNC: 8845 Entrez Gene: 5187 Ensembl: ENSG00000179094 UCSC: uc002gkd.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.239, global P-value=0.908, WHAP TDT P_sum P-value=0.595, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070888	E-box binding	Molecular Function	IDA[18411297]	4
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0032922	circadian regulation of gene expression	Biological Process	IDA[18411297]	6
GO:0009649	entrainment of circadian clock	Biological Process	TAS[9323128]	2
GO:0004871	signal transducer activity	Molecular Function		49
GO:0005634	nucleus	Cellular Component		770
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	Molecular Function	IDA[18411297]	4
GO:0000988	protein binding transcription factor activity	Molecular Function		4
GO:0007623	circadian rhythm	Biological Process	TAS[9333243]	15
GO:0009416	response to light stimulus	Biological Process		7
GO:0005737	cytoplasm	Cellular Component		690
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04710	Circadian rhythm - mammal	6

Genes shared at least 5 GO terms with PER1 (count: 8)

Gene Symbol	Pathway Count	Pathway List
PER2	7	signal transducer activity; nucleus; protein binding transcription factor activity; circadian rhythm; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
CLOCK	6	E-box binding; circadian regulation of gene expression; signal transducer activity; nucleus; RNA polymerase II core promoter proximal region sequence-specific DNA binding; circadian rhythm;
HEY2	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding transcription factor activity; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
ID2	5	negative regulation of transcription, DNA-dependent; entrainment of circadian clock; nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
MEN1	5	negative regulation of transcription, DNA-dependent; nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
RBPJ	5	negative regulation of transcription, DNA-dependent; nucleus; RNA polymerase II core promoter proximal region sequence-specific DNA binding; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
TFAP2A	5	negative regulation of transcription, DNA-dependent; nucleus; RNA polymerase II core promoter proximal region sequence-specific DNA binding; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
NCOR1	5	circadian regulation of gene expression; nucleus; cytoplasm; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with PER1 (count: 0)

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Region: chr17:8043788..8059678 View in gBrowse