ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PER2
Symbol Alias	KIAA0347
Approved Name	period homolog 2 (Drosophila)
Previous Name	period (Drosophila) homolog 2
Location	2q37.3
Position	chr2:239152679-239198743, -
External Links	HGNC: 8846 Entrez Gene: 8864 Ensembl: ENSG00000132326 UCSC: uc002vyc.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0171, global P-value=0.124, WHAP TDT P_sum P-value=0.551; OR=2.07, one or more SNPs with nominal P-value<0.05 located in this gene	Significant

Gene related SNPs (count: 15)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs880140	Chr2:239155732(Fwd)	intron_variant; nc_transcript_variant	1(1/0/0)
rs10195959	Chr2:239162318(Fwd)	3_prime_UTR_variant; intron_variant; nc_transcript_variant; synonymous_variant	1(1/0/0)
rs13382977	Chr2:239169951(Fwd)	downstream_gene_variant; intron_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs2304676	Chr2:239179914(Fwd)	downstream_gene_variant; intron_variant
rs744837	Chr2:239163744(Fwd)	intron_variant; nc_transcript_variant; non_coding_exon_variant
rs6754875	Chr2:239193219(Fwd)	downstream_gene_variant; intron_variant
rs3892365	Chr2:239163216(Fwd)	intron_variant; nc_transcript_variant
rs13002160	Chr2:239202131(Fwd)	upstream_gene_variant
rs11892306	Chr2:239188479(Fwd)	intron_variant; upstream_gene_variant
rs6431590	Chr2:239165128(Fwd)	downstream_gene_variant; intron_variant
rs11892309	Chr2:239188493(Fwd)	intron_variant; upstream_gene_variant
rs10198215	Chr2:239165909(Fwd)	downstream_gene_variant; intron_variant
rs7570188	Chr2:239172863(Fwd)	intron_variant; upstream_gene_variant
rs1972874	Chr2:239178402(Fwd)	intron_variant
rs10201361	Chr2:239173905(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	No. of Genes in ADHDgene
GO:0007623	circadian rhythm	Biological Process	15
GO:0006351	transcription, DNA-dependent	Biological Process	247
GO:0005737	cytoplasm	Cellular Component	690
GO:0005634	nucleus	Cellular Component	770
GO:0004871	signal transducer activity	Molecular Function	49
GO:0000988	protein binding transcription factor activity	Molecular Function	4
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	78

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04710	Circadian rhythm - mammal	6

Genes shared at least 5 GO terms with PER2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
PER1	7	circadian rhythm; transcription, DNA-dependent; cytoplasm; nucleus; signal transducer activity; protein binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with PER2 (count: 0)

View in gBrowse

Region: chr2:239152679..239198743 View in gBrowse