ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IL1RN
Symbol Alias	IL1RA, ICIL-1RA, IL1F3, IRAP
Approved Name	interleukin 1 receptor antagonist
Location	2q14.2
Position	chr2:113864791-113891593, +
External Links	HGNC: 6000 Entrez Gene: 3557 UCSC: uc002tjb.2
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Segman RH, 2002	Results support a small but significant contribution of the IL-1Ra VNTR to susceptibility to ADHD.	Significant
Misener VL, 2004 (b)	TDT results for the intron 2 86bp VNTR polymorphism did not support a role for the IL1RN gene in ADHD	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
IL1RN_intron2_VNTR	VNTR	intron 2	2 (1/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002439	chronic inflammatory response to antigenic stimulus	Biological Process		1
GO:0001960	negative regulation of cytokine-mediated signaling pathway	Biological Process	IDA[2137200]	1
GO:0005622	intracellular	Cellular Component	NAS[7629520]	67
GO:0005615	extracellular space	Cellular Component	IDA[12483741]	126
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770
GO:0005150	interleukin-1, Type I receptor binding	Molecular Function	IPI[1828071]	1
GO:0005149	interleukin-1 receptor binding	Molecular Function	IDA[2137200]	1
GO:0005152	interleukin-1 receptor antagonist activity	Molecular Function	IDA[2137200]; TAS[7629520]	1
GO:0005151	interleukin-1, Type II receptor binding	Molecular Function	IPI[1830582]	1
GO:0006955	immune response	Biological Process	NAS[7629520]	45
GO:0007565	female pregnancy	Biological Process		14
GO:0007613	memory	Biological Process		18
GO:0010243	response to organic nitrogen	Biological Process		4
GO:0005813	centrosome	Cellular Component		71
GO:0005886	plasma membrane	Cellular Component		772
GO:0006629	lipid metabolic process	Biological Process		51
GO:0006953	acute-phase response	Biological Process	IDA[9185517]	10
GO:0042493	response to drug	Biological Process		68
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0043507	positive regulation of JUN kinase activity	Biological Process		6
GO:0045352	interleukin-1 Type I receptor antagonist activity	Molecular Function	IDA[1828071]	1
GO:0014050	negative regulation of glutamate secretion	Biological Process		3
GO:0030073	insulin secretion	Biological Process		7
GO:0031982	vesicle	Cellular Component		6
GO:0034115	negative regulation of heterotypic cell-cell adhesion	Biological Process	IDA[2139180]	4
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	Biological Process	IDA[2137200]	1
GO:0051384	response to glucocorticoid stimulus	Biological Process	IDA[10443688]	17
GO:0045353	interleukin-1 Type II receptor antagonist activity	Molecular Function	IDA[1830582]	1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IL1RN (count: 7)

Gene Symbol	Pathway Count	Pathway List
APOA1	6	extracellular space; nucleus; plasma membrane; lipid metabolic process; response to drug; negative regulation of heterotypic cell-cell adhesion;
GSK3B	6	cytoplasm; nucleus; centrosome; plasma membrane; response to drug; negative regulation of apoptotic process;
RAB6C	5	intracellular; cytoplasm; nucleus; centrosome; response to drug;
IL16	5	extracellular space; cytoplasm; nucleus; immune response; plasma membrane;
IL6	5	extracellular space; acute-phase response; response to drug; negative regulation of apoptotic process; response to glucocorticoid stimulus;
APC	5	cytoplasm; nucleus; centrosome; plasma membrane; negative regulation of apoptotic process;
SNCA	5	cytoplasm; nucleus; plasma membrane; response to drug; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with IL1RN (count: 0)

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Region: chr2:113864791..113891593 View in gBrowse