ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CPLX1
Symbol Alias	CPX-I
Approved Name	complexin 1
Location	4p16.3
Position	chr4:778745-819986, -
External Links	HGNC: 2309 Entrez Gene: 10815 Ensembl: ENSG00000168993 UCSC: uc003gbi.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012	nominal differences were found with both adulthood ADHD and children ADHD.	Significant

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs3733358	Chr4:778599(Fwd)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)
rs6832751	Chr4:814080(Fwd)	intron_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs17165034	Chr4:798962(Fwd)	intron_variant; upstream_gene_variant
rs17165032	Chr4:798817(Fwd)	intron_variant; upstream_gene_variant
rs10155282	Chr4:814719(Fwd)	intron_variant
rs7377207	Chr4:815107(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007268	synaptic transmission	Biological Process		96
GO:0006887	exocytosis	Biological Process	TAS[7553862]	14
GO:0005829	cytosol	Cellular Component		447
GO:0005326	neurotransmitter transporter activity	Molecular Function		1
GO:0017075	syntaxin-1 binding	Molecular Function		8
GO:0016079	synaptic vesicle exocytosis	Biological Process		5
GO:0014047	glutamate secretion	Biological Process		7
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0043025	neuronal cell body	Cellular Component		51
GO:0045202	synapse	Cellular Component		31
GO:0030073	insulin secretion	Biological Process		7
GO:0030425	dendrite	Cellular Component		46
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	Cellular Component		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CPLX1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
CPLX2	6	cytosol; syntaxin-1 binding; synaptic vesicle exocytosis; neuronal cell body; synapse; dendrite;
SNAP25	5	synaptic transmission; glutamate secretion; neurotransmitter secretion; synapse; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;
SYT1	5	synaptic transmission; syntaxin-1 binding; synaptic vesicle exocytosis; glutamate secretion; neurotransmitter secretion;

Genes shared at least 2 KEGG pathways with CPLX1 (count: 0)

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Region: chr4:778745..819986 View in gBrowse