ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007189
Name adenylate cyclase-activating G-protein coupled receptor signaling pathway
Type biological process
No. of Genes in ADHDgene  11
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 11)

Literature-origin genes (count: 6)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0) IEA
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0) TAS
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0) IEA
DRD5 dopamine receptor D5 4p16.1 22(14/6/2) IDA[11500503]
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0) IDA[2144334]
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0) IEA

Genes from other sources Help (count: 5)

Approved Symbol Approved Name Source Evidence[PMID]
ADORA2A adenosine A2a receptor Mapped by CNV IEA
ADCY9 adenylate cyclase 9 Mapped by significant region TAS
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region TAS
ADCY4 adenylate cyclase 4 Mapped by significant region TAS
ADCY3 adenylate cyclase 3 Mapped by LD-proxy TAS