Gene Report
Basic Info
Approved Symbol |
PDIA6
|
Previous Symbol |
TXNDC7 |
Symbol Alias |
P5, ERp5 |
Approved Name |
protein disulfide isomerase family A, member 6 |
Previous Name |
thioredoxin domain containing 7 (protein disulfide isomerase), "protein disulfide isomerase-associated 6" |
Name Alias |
protein disulfide isomerase-related protein |
Location |
2p25.1 |
Position |
chr2:10923517-10978103, - |
External Links |
HGNC: 30168
Entrez Gene: 10130
Ensembl: ENSG00000143870
UCSC: uc002rau.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 15)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04141 |
Protein processing in endoplasmic reticulum |
26 |
The endoplasmic reticulum (ER) is a subcellular organelle wh......
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
More...
|
Genes shared at least 5 GO terms with PDIA6 (count: 9)
Genes shared at least 2 KEGG pathways with PDIA6 (count: 0)
View in gBrowse