Study Report

Basic Info
Reference |
Lowe N, 200111378856
|
Citation |
Lowe N., Hawi Z., Fitzgerald M. and Gill M. (2001) "No evidence of linkage or association between ADHD and DXS7 locus in Irish population." Am J Med Genet, 105(4): 394-5.
|
Study Design |
family-based |
Study Type |
Candidate-gene association study |
Sample Size |
79 ADHD children and their parents |
Predominant Ethnicity |
Caucasian |
Population |
Ireland |
Gender |
10 females and 68 males |
Age Group |
Children/Adolescents
|

Detail Info
Summary |
They have examined the microsatellite marker DXS7 in 79 affected children and their parents. All children were diagnosed according to the DSM-IV. Ten of the affected children were female, while the remaining 68 were male. The TDT and HHRR values observed were not significant. However, their samples are from different ethnic backgrounds, and only one polymorphism has been tested. Given the history of false positive and negative findings in the field of psychiatric genetics, further studies are required to explore the observation reported by Jiang et al. [2000]. The microsatellite marker DXS7 is known to be closely linked to the MAO genes [Moore et al., 1992; Jiang et al., 2000]. |
Total Sample |
The sample consisted of 79 affected children and their parents. |
Diagnosis Description |
All children were diagnosed according to the DSM-IV |
Technique |
no description in the original publication |
Analysis Method |
TDT analysis and HHRR analysis were used in this study |
Result Description |
The TDT (chi-square=1.06, P=0.39) and HHRR (chi-square=0.19, P=0.66) values observed were not significant. No preferential transmission of the 157 bp allele or any other allele was observed in this samples. |

Other variant reported by this study (count: 1)
Variant Name |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
MAOA DXS7 |
|
|
TDT P-value=0.39, X2=1.06; HHRR P-value=0.66, X
TDT P-value=0.39, X2=1.06; HHRR P-value=0.66, X2=0.19
More...
|
there was no significant association with ADHD in this study |
Non-significant
|

Genes reported by this study (count: 1)
Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
MAOB |
there was no significant association with ADHD in this study
there was no significant association with ADHD in this study
|
Non-significant
|