ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Lowe N, 200111378856
Citation	Lowe N., Hawi Z., Fitzgerald M. and Gill M. (2001) "No evidence of linkage or association between ADHD and DXS7 locus in Irish population." Am J Med Genet, 105(4): 394-5.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	79 ADHD children and their parents
Predominant Ethnicity	Caucasian
Population	Ireland
Gender	10 females and 68 males
Age Group	Children/Adolescents

Detail Info

Summary	They have examined the microsatellite marker DXS7 in 79 affected children and their parents. All children were diagnosed according to the DSM-IV. Ten of the affected children were female, while the remaining 68 were male. The TDT and HHRR values observed were not significant. However, their samples are from different ethnic backgrounds, and only one polymorphism has been tested. Given the history of false positive and negative findings in the field of psychiatric genetics, further studies are required to explore the observation reported by Jiang et al. [2000]. The microsatellite marker DXS7 is known to be closely linked to the MAO genes [Moore et al., 1992; Jiang et al., 2000].
Total Sample	The sample consisted of 79 affected children and their parents.
Diagnosis Description	All children were diagnosed according to the DSM-IV
Technique	no description in the original publication
Analysis Method	TDT analysis and HHRR analysis were used in this study
Result Description	The TDT (chi-square=1.06, P=0.39) and HHRR (chi-square=0.19, P=0.66) values observed were not significant. No preferential transmission of the 157 bp allele or any other allele was observed in this samples.

Other variant reported by this study (count: 1)

Genes reported by this study (count: 1)